Master Formula

Longevity Foundation Supplement Facts table

Master Formula

Longevity Foundation

Welcome to the future of anti-aging. Devised by world-leading longevity experts, our foundational formula works around the clock to tackle aging at its roots, addressing all 12 known drivers of aging with precision. Our pioneering time-released AM/PM system, tailored to your body's natural rhythms, enables precision targeting, like having the guidance of a longevity clinician, 24/7. Formulated to modulate crucial longevity mechanisms like AMPK, mTOR, sirtuins signaling pathways, NAD+ levels, mitochondrial health, and cellular renewal, the combination helps support younger skin, a sharper mind, and a stronger body. With Longevity Foundation, you're challenging the very core of aging biology, with ingredients backed by 100+ studies.

The #1 longevity protocol
Highest-grade, clinical dosages
Doctor formulated
Powerful results

One month supply: 1 pouch AM + 1 pouch PM
Charged once

Cancel anytime

No commitment

Quantity

Subscribe and save 25%. Subscription details.

As seen in

Two powerful formulas, one complete longevity regimen

The most advanced, targeted, anti-aging system to address all 12 hallmarks of aging, 24/7

Why it’s different

Targets All 12 Hallmarks Of Aging
2-Part Formula with 24/7 Precision

Longevity Foundation revolutionizes anti-aging by meticulously targeting all ‘12 hallmarks of aging’ (1, 2). Unveiled over the past decade, these 12 processes (commonly known as ‘aging’), impacting molecular, cellular, and systemic levels, is the primary risk factor for most chronic diseases. Our formula transcends traditional approaches, addressing the intricate web of aging - from chronic inflammation to cellular energy dysfunction, and DNA damage to the proliferation of senescent ‘zombie’ cells (3). Each hallmark interconnects, impacting molecules, cells, and your overall bodily health. The Longevity Foundation's dual AM/PM regimen is expertly engineered to work synergistically, offering full-spectrum, 24/7 support against these fundamental drivers of aging.
Unlike 'all-in-one' strategies that don’t align with your body’s internal timing—such as by taking energizing ingredients when it’s time to rest or prompting repair mechanisms when your body is in an active mode, our AM and PM formulations work synergistically with your body's day-night cycle. The AM formula helps keep you sharp and energized during the day while providing protection from sun exposure in your skin. The PM formula helps enhance whole-body regenerative mechanisms that are most active while you sleep.
Can you take the AM/PM dose together if you’re busy? Of course, taking both doses together is perfectly fine. Whether you take them separately or together, you're still providing your body with essential support against the drivers of aging.
Younger Skin From Within
Foundational Dermal Longevity

Your skin, the body's largest organ, is crucial in defending against environmental stressors that accelerate aging. It’s also the site of the body’s largest building of senescent cells that don’t just age your skin, but your whole body. The AM formula is designed to bolster daytime anti-aging & defense mechanisms. Niacin improves blood circulation and lipid profiles, which can enhance skin health by delivering essential oxygen, nutrients, and antioxidants to skin cells while removing waste. Niacin also aids energy production by contributing to increased NAD+ levels, and improves skin barrier function, supporting moisture retention and elasticity. As powerful antioxidants, pterostilbene and fisetin can help protect the skin from damage caused by free radicals, which can accelerate skin aging (11, 16). Quercetin has been found to protect the skin from the effects of photoaging caused by exposure to the sun’s dangerous UVB radiation (17).
At night, the PM formula is hard at work bolstering and rejuvenating your skin. Astaxanthin, often described as an 'internal sunscreen,' builds up in skin over time, acting as a powerful UVB absorber, reduces DNA damage, and is a natural anti-inflammatory, effectively preventing wrinkles, dry skin, age spots, and hyperpigmentation. Studies show that astaxanthin can start improving skin health visibly within just two weeks, reversing signs of premature aging and enhancing your body’s defenses against sun exposure (12, 18, 19). Zinc and olive leaf extract help support overnight wound healing, reduce skin inflammation, and are deeply involved in collagen synthesis (20-23), while apigenin has shown potential to protect skin from oxidative stress, reduce inflammation, inhibit the activity of enzymes involved in skin aging, and promote collagen synthesis, an essential component for skin elasticity and firmness (24, 25).
Spermidine plays a crucial role by promoting autophagy, which aids in the elimination of senescent cells in the skin that contribute to aging and skin deterioration. This process reduces the accumulation of damaged cells, thereby enhancing skin rejuvenation and potentially delaying signs of aging (13, 26, 27).
Multi-Modal Cellular Clean-up
Stimulates Autophogy, activates AMPK, mTOR, and SIRT1

Autophagy is a natural process where cells break down and recycle old parts, removing damaged proteins and organelles and aiding in cellular repair. Often modulated via AMPK/mTOR pathway, it’s one of the most powerful age-reversal mechanisms your body can employ, and can be induced through lifestyle hacks such as cold plunges, intermittent fasting, and high intensity exercise.
Longevity Foundation makes it easier, by having a round-the-clock cellular clean-up crew tirelessly working to enhance autophagy for your longevity. The powerful 2-part system employs critical autophagy-promoting compounds, to revitalize your cells day and night. These Longevity Foundation compounds mimic calorie restriction, due to activation of the same signaling pathways, such as AMP-activated protein kinase (AMPK), the mammalian target of rapamycin (mTOR) pathway, and the silent information regulator 1 (SIRT1) pathway, leading to increased autophagy and improved cellular function. By emulating these effects, Longevity Foundation is like 'calorie restriction in a bottle', offering a convenient, supplement-based approach to achieve the benefits of calorie restriction without the need to significantly alter dietary intake.

During the day, quercetin from AM formula activates the AMPK/mTOR pathway, SIRT1 pathway, and the extracellular signal-regulated kinase (ERK) pathway. Quercetin's ability to modulate these pathways can stimulate autophagy and enhance cellular clearance (28, 29). Pterostilbene has also been reported to induce autophagy by activating the AMPK pathway and inhibiting the mTOR pathway(30).

At night, olive leaf extract, fisetin, and spermidine deepen the work. Olive leaf extract has been shown to activate the AMP-activated protein kinase (AMPK) pathway, leading to the induction of autophagy, and modulating the sirtuin pathway, particularly SIRT1 - making it clear why high-polyphenol, olive-oil rich Mediterranean diets are associated with remarkable longevity (31). Olive leaf extract and spermidine have both been shown to induce autophagy by activating the AMPK pathway and inhibiting the mammalian target of rapamycin (mTOR) pathway, both involved in longevity (26, 31). Spermidine inhibits the enzyme EP300, leading to reduced histone acetylation and thus activating autophagy-related genes (27, 32). It can also promote autophagosome formation, which engulfs damaged proteins or organelles, fuses with lysosomes to form autolysosomes, to be broken down and recycled, inhibiting autophagy-disrupting enzymes (26, 27, 33).
Enhanced Cognition
With Sharp Days, and Calm Nights

Ever struggled with foggy mornings or restless nights? Longevity Foundation provides a finely balanced day and night formula to boost mental performance and support cognitive longevity on the deepest levels. Your AM dose starts with the energy-boosting power of quercetin, which increases cellular energy expenditure by enhancing oxygen consumption in your muscles giving you a whole-body performance boost (34). Niacin is a powerful nutrient to help maintain your mental sharpness (35, 36). It is a key component of coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate), which are essential for energy metabolism in the brain. As an energy-intensive organ, the brain heavily relies on these coenzymes for its energy needs and proper functioning (35, 37). In fact, brain fog and even psychiatric symptoms are associated with niacin deficiency. Population studies show that people who get higher levels of niacin in their diet have a lower risk of Alzheimer's disease (38). As your day unwinds, astaxanthin in your PM dose shields your brain from age-related damage by boosting neurotrophic factor levels, reducing oxidative harm to lipids, proteins, and DNA, and safeguarding mitochondrial function (39). Spermidine promotes cellular renewal and autophagy, which have been linked to improved brain function and possibly slowed cognitive decline (40). Olive leaf extract enhances blood flow to the brain, reducing oxidative stress and inflammation, which are key factors in cognitive decline (15, 41). And to ease you into a restful sleep, apigenin helps with science-backed calming effects and sleep-enhancing properties (14, 42).
Synergistically Boost NAD+
Move over, NMN

NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme involved in cellular health and energy metabolism. It aids in DNA repair and supports the activity of "longevity proteins" called sirtuins. As NAD+ levels decrease with age, it can affect these critical processes, potentially leading to signs of aging and age-related diseases. By supporting NAD+ levels, Longevity Foundation promotes health and slow aging-related changes (75-77). Niacin is a well studied precursor to NAD+, and unlike other NAD+ boosters like NMN or NR, Niacin has been thoroughly studied in human trials for decades, and has been shown to cure NAD deficiencies in humans (37, 57). When ingested, niacin can be converted into NAD+ in the body, helping maintain or increase NAD+ levels. This is one of the ways niacin may promote cellular health and, by extension, potentially contribute to longevity (57, 78-80).
But Longevity Foundation does not stop supporting NAD+ levels with Niacin alone.
Apigenin provides powerful NAD+ synergy. It has been shown to modulate the activity of certain enzymes (particularly CD38) involved in NAD+ metabolism, such as nicotinamide phosphoribosyltransferase (NAMPT), which is responsible for the conversion of nicotinamide to nicotinamide mononucleotide (NMN), a precursor of NAD+. By affecting NAMPT activity, apigenin may potentially influence NAD+ levels. Some studies have suggested that apigenin can increase NAD+ levels and activate the NAD+-dependent protein deacetylase sirtuin 1 (SIRT1), which is involved in various cellular processes related to aging and longevity. Activation of SIRT1 by apigenin could potentially impact cellular metabolism, DNA repair, and other NAD+-dependent pathways (82, 83).
Finally, Pterostilbene is a sirtuin activator, and sirtuins are a family of proteins that rely on NAD+ to function. While pterostilbene does not directly increase NAD+ levels, activating sirtuins may enhance the cellular processes that NAD+ is involved in, potentially contributing to benefits related to health and longevity (81).
Strengthen Muscles, Nourish Joints
Because Movement Keeps You Young

Our Longevity Foundation formula provides round-the-clock support for your muscular and skeletal health. During the day, you can leverage the benefits of alpha-ketoglutarate (AKG), a supplement renowned in the bodybuilding world that also exhibits remarkable life-extension properties. It is a key component of the Krebs cycle, and is known to promote muscle protein synthesis, contributing to the maintenance and growth of muscle mass (56). Niacin, or vitamin B3, plays a pivotal role in energy production and metabolism, essential for maintaining muscle function and health (57). As night falls, zinc is fundamental for numerous biological processes, including protein synthesis and cell division, processes vital for muscle tissue repair and growth (58). Oleuropein found in olive leaf extract is an activator of protein called Mitochondrial Calcium Uniporter (MCUR1), enhancing mitochondrial respiration and energy metabolism. This boosts endurance and reduces fatigue in muscles/The effectiveness of oleuropein is linked to its action on the mitochondrial calcium uptake mechanism, suggesting its potential as a therapeutic nutrient for improving muscle health and performance in aging (59).

Chondroitin sulfate is well known for its benefits to joint health; it provides the necessary components for the body to produce new cartilage, contributing to overall joint health and function, and it also has anti-inflammatory properties (60). Lastly, astragalus root extract, traditionally used in various health conditions, including arthritis, is believed to possess anti-inflammatory effects that could benefit joint health, particularly in reducing inflammation associated with various joint disorders (61). With Longevity Foundation, muscle and joint support does not skip a beat—even as you sleep.
Improved Cellular Energy & Vitality
Mitochondria Fuel & Metabolic Flexibility

Alpha-Ketoglutarate (AKG), spermidine, and astaxanthin in Longevity Foundation are dynamic nutrients that feed your mitochondria and enhance your metabolic flexibility.

Metabolic flexibility refers to the body's ability to efficiently switch between burning different types of fuel, primarily carbohydrates and fats, based on availability and energy demand. Metabolic flexibility helps you skip meals without getting grumpy and eat high carbs without feeling bloated. This adaptability is crucial for maintaining energy balance, optimal physical performance, and overall metabolic health. Good metabolic flexibility helps manage blood sugar levels, reduce the risk of metabolic disorders like diabetes, and support effective weight management (62, 63). AKG, at the heart of the Krebs cycle, fuels mitochondrial energy production, boosting the mitochondria's ability to convert nutrients into energy efficiently. This process feeds the mitochondria and fortifies their resilience against oxidative stress (64, 65). Spermidine plays a pivotal role in mitochondrial quality control through mitophagy, ensuring the clearance of underperforming mitochondria and reinforcing their overall health and efficiency (66, 67). Research suggests that oleuropein may help improve insulin sensitivity and regulate blood sugar levels, which is beneficial for managing conditions like diabetes. Additionally, it has been shown to have anti-inflammatory and antioxidant properties, which can contribute to overall metabolic health by reducing oxidative stress and inflammation in the body (68-70). Finally, astaxanthin, with its potent antioxidant properties, acts as a guardian for mitochondria, shielding them from oxidative damage and contributing to their optimal functioning (71, 72).
Shield Cells From Oxidative Stress
Defy reactive oxygen species (ROS)

Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and the ability of the body to neutralize their harmful effects through antioxidants. Reactive oxygen species are totally natural byproducts of metabolic processes that occur in the body (4, 5).
Oxidative stress is considered detrimental to longevity because it contributes to the damaging of cellular components, including DNA, leading to a decline in cellular function, an increased susceptibility to age-related diseases, and accelerated aging. Therefore, managing oxidative stress and maintaining a balance between ROS production and antioxidant defense is important for promoting longevity and overall health (6, 7).

Longevity Foundation contains carefully selected antioxidants across both AM and PM doses. The AM dose is engineered with pterostilbene (8), quercetin (9), alpha-ketoglutarate (AKG) (10), fisetin (11), and astaxanthin, renowned for its extraordinary potency, being 6000x more powerful than vitamin C, while the PM dose incorporates potent antioxidants like spermidine (13), apigenin (14) and olive leaf extract (15). Together, they neutralize free radicals and provide potent oxidative protection to your cells. Consider this your personal shield against aging all day long.
Fortify Immunity, Target 'Inflammaging'
A newly adopted Hallmark of aging

Aging and related diseases often share a common denominator: persistent, non-infection-related inflammation, aptly termed 'inflammaging'. This detrimental process stems from a dysregulated immune system as we age. Our Longevity Foundation formula is designed to counter this, packing multiple compounds with potent anti-inflammatory properties. Pterostilbene, a compound closely related to (but more bioavailable than) resveratrol, has powerful anti-inflammatory and antioxidant activities and is capable of modulating molecular pathways implicated in inflammation and oxidative stress and combating inflammaging (8, 73, 74).
Quercetin as well as olive leaf extract exhibits strong anti-inflammatory and antioxidant properties. Its effects include inhibiting the production and activity of pro-inflammatory molecules, suggesting a significant role in ameliorating inflammaging (9, 68). Lastly, spermidine, a naturally occurring polyamine, is a promising agent against inflammaging due to its role in inducing autophagy, a cellular process implicated in regulating inflammation and the potential to suppress pro-inflammatory signaling pathways (26). All of them team up to stabilize cells that release inflammation-triggering histamine. The result? A fortified immune system and a strong front line against 'inflammaging'.
Supports Telomerase Activity
Protecting Shortened Telomeres, A Hallmark of Aging

Longevity Foundation is crafted to target telomere health, crucial in slowing cellular aging and one of the original hallmarks of aging. Telomeres, the protective caps at the ends of chromosomes, naturally shorten over time, leading to cellular aging. Shorter telomeres are associated with decreased longevity (43-45). Longevity Foundation features a strategic blend of ingredients chosen for their impact on telomere health. Astragalus root extract, a key component of our formula, is celebrated for its ability to stimulate telomerase activity. Telomerase is an enzyme that adds sequences to the ends of telomeres, potentially extending their length and combating the natural progression of cellular aging. This process is crucial as it directly counters the shortening of telomeres, promoting healthier and more resilient cells, essential for longevity(46). Complementing this, spermidine, another integral ingredient, aids in reducing telomere erosion, particularly in vital organs. By supporting the body's natural autophagy processes and protecting against oxidative stress, spermidine effectively removes damaged cellular components, helping maintain telomere integrity and enhance overall cellular vitality (47). This synergistic blend in Longevity Foundation offers a comprehensive approach to maintaining telomere length, a key to longevity and robust cellular health.
Improved Gut Microbiome Balance
A newly adopted Hallmark of aging

Imbalances in the gut microbiome, known as gut dysbiosis, can trigger low levels of essential substances necessary for healthy digestion and basic nutrient absorption. As of 2023, such imbalances are now classified as core drivers of aging (48). Longevity Foundation helps manage this thanks to niacin, quercetin, zinc, and astragalus root extract.
Niacin, or vitamin B3, can help with dysbiosis, as certain gut bacteria can synthesize B vitamins, including niacin. When these bacteria have access to ample niacin, they can effectively carry out their metabolic functions and grow instead of focusing on vitamin synthesis, which promotes their population growth This can potentially counter dysbiosis. Niacin also has anti-inflammatory properties, which are beneficial in conditions of gut dysbiosis that are often associated with inflammation. Furthermore, niacin may help maintain the integrity of the gut barrier by increasing mucus production in the gut, preventing the adherence and invasion of pathogenic bacteria (49, 50).
Quercetin is believed to have prebiotic effects, meaning it can serve as a nutrient source for specific beneficial bacteria, allowing them to proliferate and potentially counteract dysbiosis by enhancing their population. It has anti-inflammatory and antioxidant properties helping reduce inflammation often associated with gut dysbiosis. By reducing inflammation, quercetin can help maintain the integrity of the gut barrier, which is typically compromised in dysbiosis (51, 52). Spermidine helps in decreasing intestinal inflammation through several mechanisms. It encourages the development of anti-inflammatory macrophages, supports the maintenance of a balanced gut microbiome, and aids in preserving the integrity of the epithelial barrier (53).
Finally, polysaccharides from astragalus root extract also have prebiotic function. Additionally, they may interact with the gut-associated lymphoid tissue, the largest immune organ in the body, to enhance immune responses. This can help maintain a healthy balance of gut microbiota and prevent the overgrowth of harmful bacteria (54, 55).

How to use

Healthy adults should take two (2) Longevity Foundation AM tablets daily in the morning, and two (2) Longevity Foundation PM tablets nightly before bed, with or without food. For improved absorption and metabolism, ensure adequate water intake. This product is formulated based on chronobiology principles to support your body's natural physiological rhythms in the morning and is designed to work synergistically with your PM serving. However, if preferred, you can take both AM and PM servings together at any time of the day without compromising the benefits.

+ behavioral protocol

Longevity Foundation is not a replacement for healthy lifestyle choices like diet, exercise, and sleep. That's precisely why Jung's Total Longevity System™ allows you to amplify the effectiveness of longevity molecules with precision-engineered lifestyle boosters. Combine Longevity Foundation with a lifestyle booster for optimal effect.

+ Warning

Not recommended for children, pregnant or nursing women, or individuals taking immune-suppressing drugs, warfarin, and certain other medications. People with immune system diseases, peptic ulcer disease, liver or kidney disease, hypertension, low blood calcium levels, low blood pressure, parathyroid disorders, or those allergic or hypersensitive to any component of the formulas should avoid use.

you, like new

Look inside

AM - Niacin

200 mg

Niacin, essential for energy production, DNA repair, and skin health, plays a vital role in cellular metabolism and longevity. It’s a well studied precursor to NAD+, a coenzyme essential for cellular processes. NAD+ declines with age. Unlike popular NAD+ boosters (NMN or NR), Niacin has been thoroughly studied in human trials for decades, and has been shown to cure NAD+ deficiencies in humans. It's also linked to heart health by lowering cholesterol, and to brain health by generating key brain chemicals. Our formula is engineered with a "no flush niacin" (inositol hexanicotinate), which provides niacin's benefits without the common flushing reaction, ensuring a steady conversion in the body to niacin and inositol (57, 79, 84, 85).
AM - Pterostilbene

100 mg

Pterostilbene, a naturally occurring compound found in blueberries and grapes, is known for its potent antioxidant, anti-inflammatory, and repair properties. It can also activate sirtuins, a family of proteins that help maintain the epigenome, and play a vital role in maintaining cellular health and extending lifespan, earning them the moniker "longevity genes". Pterostilbene is a cousin of ‘resveratrol’, which although popularly marketed, has unfortunately been found to be poorly-absorbable by humans, making pterostilbene (found to be bioavailable in humans) the superior choice. Additionally, some research suggests pterostilbene may aid in blood sugar control, crucial to healthy longevity (8, 16, 30, 73, 74). You would need to eat over 1 kg of blueberries to get a comparable amount of pterostilbene in Longevity Foundation.
AM - Quercetin

200 mg

Quercetin is a flavonoid with potent antioxidant properties found in various fruits and vegetables. It's known for its ability to scavenge free radicals, mitigating oxidative stress. Quercetin exhibits anti-inflammatory properties, helping to calm chronic inflammation - a Hallmark of Aging. Quercetin is considered a senolytic, which means it can clear senescent cells - another Hallmark of Aging - the zombie or damaged cells that no longer divide but contribute to inflammation and age-related diseases (9, 17, 28, 29, 87). Apples, onions, berries, capers, and leafy greens are particularly high in quercetin, but to reach 200 mg of quercetin in Longevity Foundation, you would need roughly 15 apples in a day.
AM - Calcium Alpha-Ketoglutarate

1,000 mg

Calcium Alpha-Ketoglutarate (Ca-AKG), plays an integral role in the body's metabolic processes, particularly the Krebs cycle, involved in energy production and nutrient metabolism. Ca-AKG reduces inflammation and supports cellular health, both key elements in promoting longevity. It may aid in removing senescent “zombie” cells that accumulate with age and can contribute to various aging-related diseases (89, 90). Alpha-ketoglutarate was shown to reduce biological age by 8.44 years for men and 6.98 years for women when measured by the TruAge DNA methylation test after an average of 7 months of use (91). AKG significantly extends the lifespan of C. elegans nematode be even 50% through inhibition of ATP synthase and TOR signaling (92).
AM - Fisetin

50 mg

Fisetin is a flavonoid polyphenol found in various fruits and vegetables. Fisetin is recognized for its potent antioxidant properties that help neutralize harmful free radicals and reduce oxidative stress, contributing to aging. Additionally, fisetin has senolytic properties, meaning it can selectively target and remove senescent or "zombie" cells. Thus, fisetin can potentially support longevity through its dual action of antioxidant and senolytic activity (11, 93-96). Fisetin may also mimic caloric restriction thanks to its sirtuin activation ability, and delays aging in fruit flies by 23% (97). To reach 50 mg of fisetin included in Longevity Foundation, you would have to consume 8.3 pounds of strawberries.
AM - Astaxanthin

3.5 mg

Astaxanthin, a naturally occuring carotenoid, is a red-pink pigment found in marine organisms like salmon, krill (and even flamingos!). Known as the queen of antioxidants, its power is up to 800x more potent than Co-Q10 or 6000x more powerful than Vitamin C, helping it combat oxidative damage, shielding age-accelerating damage at a cellular level. Astaxanthin contributes to cardiovascular health by reducing inflammation and oxidative stress in blood vessels, potentially protecting against neurodegenerative conditions like Alzheimer's and Parkinson's diseases by decreasing inflammation and oxidative damage in the brain. It is also beneficial for skin health, demonstrating a capacity to shield skin from UV light damage, minimizing wrinkles, and enhancing skin elasticity (12, 39, 101-103). Our Astaxanthin is sourced from Algae (which is where Salmon get it too).
PM - Spermidine

2.5 mg

Spermidine, a natural polyamine, has garnered significant interest for its potential impact on longevity and overall health. It promotes cellular renewal, supporting skin youthfulness through autophagy and brain health by removing damaged cell components, aiding cognitive function and possibly preventing age-related decline. Spermidine also maintains gut microbiome balance and intestinal health. Additionally, it offers cardiovascular benefits, potentially reducing heart disease risk by improving heart cellular health. Its role in longevity is linked to enhanced mitochondrial function and cellular metabolism, vital in aging (13, 26, 27, 32, 67, 98, 99).
PM - Zinc

10 mg

Zinc, vital for cellular metabolism, influences over 300 enzymes and 2,000 gene-controlling transcription factors. Essential for immune response, protein synthesis, wound healing, and DNA synthesis, it bolsters immunity, reduces inflammation, and enhances antioxidant activity, promoting longevity. Zinc deficiency can cause growth issues, weak immunity, skin disorders, and cognitive problems, highlighting its necessity for health (20, 21, 36, 105-107). Research indicates zinc may aid sleep regulation, making it part of our PM formula (108, 109). The zinc dose in Longevity Foundation is equivalent to about 1 kg of cooked chicken.
PM - Oleuropein (Olive Leaf Extract)

650 mg

Oleuropein (via Olive Leaf Extract), the main polyphenol found in extra virgin olive oil, mirrors one of the key benefits central to the Mediterranean diet. Oleuropein stimulates autophagy via the powerful AMPK/mTOR signaling pathway, the body's process of clearing out damaged cells, which can lead to better cellular health and longevity, as well as fights inflammation linked to age-related diseases, and may boost cognition and memory, protecting against cognitive decline (31, 41, 68, 111). This phenolic compound has powerful antioxidants, reducing oxidative stress, a major aging factor, and aiding in diminishing skin aging signs. It supports muscle health, metabolic disease protection, and is renowned in lowering blood pressure, showcasing cardioprotective and neuroprotective properties. Oleuropein lessens oxidative brain damage, counters Alzheimer's-related protein aggregation, and inhibits growth factors overexpressed in certain breast cancers (59, 69, 70, 110). A ‘High polyphenol’ olive oil is considered to have at least 250 mg of polyphenols per kilogram of olive oil - you would need to consume at least 2 kilograms of olive oil to receive the equivalent serving of Oleuropein in a single dose of Longevity Foundation.
PM - Astragalus

100 mg

Astragalus root extract, used in traditional Chinese medicine, is known for boosting immunity and potentially slowing aging at a cellular level. Its active components, astragalosides and polysaccharides, have anti-inflammatory and antioxidant properties. Studies indicate astragalus may protect telomeres, chromosome ends that degrade over time - a Hallmark of Aging - thereby influencing longevity (46, 112-114). Since immune response varies by time, its inclusion in our PM formula optimizes its effects. Astragalus also affects DAF-15/FOXO transcription factors in C.elegans, extending its lifespan by over 23% (115), highlighting its impact on longevity.
PM - Chondroitin

700 mg

Chondroitin sulfate, naturally in body cartilage, is recognized for its potential benefits in managing osteoarthritis symptoms. It enhances cartilage elasticity and resistance to compression, reducing joint pain and improving function. While its direct impact on longevity is subtle, promoting joint health and mobility contributes to optimized physical performance over time. In vitro studies indicate it may also reduce inflammation. Chondroitin sulfate is not typically found in significant amounts in the standard diet, and is primarily extracted for use in supplements (116-120).
PM - Apigenin

50 mg

Apigenin, a flavonoid commonly found in plants and herbs, possesses antioxidant, anti-inflammatory, and anticancer qualities. It promotes cellular homeostasis, crucial for cell health and function, countering stressors like inflammation and oxidative damage. Apigenin modulates cellular senescence and autophagy, key aging-related processes, and is involved in NAD+ metabolism, highlighting its role in maintaining cellular vitality (14, 24, 42, 121).

What are the 12 hallmarks of aging, how can they be addressed?

Learn more

Age is the single largest risk factor for an enormous number of diseases. So, if you can essentially postpone aging, then you can have beneficial effects on a whole wide range of disease.

Dr. Cynthia Kenyon, molecular biologist and pioneer in aging research

Scientific studiеs

Niacin is a precursor for the coenzyme NAD+.

By examining various studies and reports on the topic, it is evident that nicotinamide, the amide form of niacin, plays a crucial role in cell survival and longevity. Obtaining an adequate amount of vitamin B3 enhances the ability of nicotinamide to maintain cellular integrity and reduce inflammation. This process is achieved by influencing several cellular targets, such as mitochondrial membrane potential, poly (ADP-ribose) polymerase (PARP), protein kinase B (Akt), caspases, and microglial activation (122).
Fisetin is a senotherapeutic that might extend health and lifespan

The study found that fisetin, a flavonoid present in many fruits and vegetables, is highly effective in combating cellular aging. Fisetin was the most potent among various flavonoids tested for eliminating senescent cells, which are cells that cease to divide and contribute to aging and age-related diseases. When administered to mice, both in models of accelerated aging and in normal aged mice, fisetin significantly reduced markers of cellular aging in various tissues and was effective with both short-term and intermittent treatments. Notably, fisetin's use in normal, aged mice led to improved tissue health, reduced age-related pathologies, and importantly, extended their overall lifespan, highlighting its potential as a therapeutic agent for aging and associated diseases (95)
Pterostilbene has become an attractive drug candidate for treating several disease conditions.

Pterostilbene (PTS) has gained attention for its therapeutic potential in various diseases due to its improved absorption and stability compared to resveratrol. PTS shows promise in addressing conditions such as diabetes, cancer, cardiovascular disease, neurodegenerative disorders, and aging. This review highlights the nutraceutical potential of PTS and explores its mechanisms of action, focusing on its Nrf2-mediated effect in diabetes. It also discusses the sources of PTS, its pharmacokinetics, different formulations and administration routes used in studies and clinical trials, and strategies to enhance its availability and accessibility (73).
Induction of autophagy by spermidine promotes longevity

Spermidine, a natural polyamine found to decline with age, has emerged as a significant factor in promoting longevity. This groundbreaking study reveals that spermidine supplementation remarkably extends the lifespan of yeast, flies, worms, and even human immune cells. Moreover, it offers potent protection against oxidative stress in aging mice. The key to spermidine's efficacy lies in its ability to induce epigenetic changes, particularly the deacetylation of histone H3. This process, driven by the inhibition of histone acetyltransferases (HAT), leads to reduced oxidative stress and necrosis in aging yeast. On the flip side, reduced levels of endogenous polyamines correlate with increased acetylation, reactive oxygen species production, early necrotic death, and a shortened lifespan. Spermidine's impact extends to upregulating autophagy-related transcripts, thereby triggering autophagy in various organisms and human cells. This enhanced autophagy is essential for spermidine's role in suppressing necrosis and boosting longevity, underscoring its potential as a powerful anti-aging intervention (22).
Quercetin causes apoptosis in the A-549 lung cancer cell lines.

This study investigates the anticancer effects of quercetin (QC) on the A-549 human lung cancer cell line. Researchers observed that QC notably inhibited cell growth in a dose-dependent manner and induced apoptosis, an effect that was even more pronounced with increased treatment duration. When examining the molecular mechanisms involved, the study found that QC treatment led to decreased expression of the anti-apoptotic gene bcl-2 and increased expression of the pro-apoptotic gene bax. These effects were also confirmed in vivo, using A-549 cell xenografts in mice, showing tumor growth inhibition and induction of apoptosis. Thus, the study concludes that QC's anticancer effects on A-549 cells may be attributed to its ability to regulate key genes involved in apoptosis (123).
Higher spermidine intake is linked to lower mortality

The study investigated the relationship between dietary spermidine intake and mortality in humans. It involved 829 participants aged 45–84 years and used repeated, dietitian-administered food-frequency questionnaires over a period from 1995 to 2015. The results showed that all-cause mortality decreased with increasing spermidine intake. For instance, mortality rates per 1000 person-years were lower in groups with higher spermidine intake, corresponding to a reduced cumulative mortality incidence over 20 years. The hazard ratio (HR) for all-cause death per one standard deviation higher spermidine intake was significantly lower, suggesting a reduced risk of death with higher intake. This association was consistent across different subgroups and was also validated in a separate study. The study concluded that a diet rich in spermidine is linked to increased survival, with the mortality risk reduction between the highest and lowest spermidine intake groups comparable to being younger by approximately 5.7 years. This supports the idea that spermidine-rich nutrition can contribute to increased human longevity (98)
Alpha-ketoglutarate may extend human healthspan.

Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle with diverse metabolic and cellular functions. It acts as an antioxidant, influencing nitrogen and ammonia balance and impacting epigenetic and immune regulation. These multifaceted properties suggest that AKG may potentially enhance human healthspan. Recent studies in worms and mice support this hypothesis. This review will focus on the regulatory role of AKG in aging and its potential as a treatment for age-related diseases (89).
Astaxanthin can modulate Nrf2, FOXO3, Sirt1, and Klotho proteins linked to longevity.

Astaxanthin (ASX) is a natural compound that shows promising geroprotective properties. Its polyene chain allows it to scavenge free radicals in cell membranes and control oxidation. ASX has also been found to modulate various cellular mechanisms related to longevity, including the FOXO3 gene, a crucial regulator of cell function and longevity. ASX has shown neuroprotective effects, particularly in aging and neurodegenerative models, by increasing brain-derived neurotrophic factor levels, reducing oxidative damage, and preserving mitochondrial function. ASX can also influence proteins such as Nrf2, Sirt1, and Klotho associated with longevity. These findings suggest that ASX may have the potential as a geroneuroprotector (39).
Supplementation with olive leaf extract ameliorates age-related vascular and metabolic changes in Wistar rats.

This study analysed the impact of olive leaf extract (OLE), rich in secoiridoids and phenolic compounds, on aging-induced metabolic and vascular alterations in rats. The supplementation with OLE in aged rats showed a prevention of loss in body weight and muscle mass, and a reduction in the weight of adrenal glands. In terms of serum changes, OLE effectively lowered LDL-cholesterol and IL-6 levels, while increasing leptin and adiponectin concentrations. In the liver, OLE moderated the age-induced changes in gene expression, notably reducing the overexpression of NOX-4, Alox-5, iNOS, and TNF-α, and supporting the expression of SOD-1, GSR, GCK, and GSK-3β. Furthermore, OLE demonstrated a significant improvement in vascular function in aged rats, evidenced by the prevention of endothelial dysfunction, enhancement of vascular insulin resistance, and improved vasoconstriction response to KCl and NA. This improvement in vascular function was associated with the attenuation of alterations in the gene expression of key markers such as COX-2, IL-6, GPx, NOX-1, and IL-10. The study concluded that OLE exerts anti-inflammatory and antioxidant effects in aged rats and attenuates the alterations in vascular function associated with aging (124).
The extract component of Astragalus membranaceus can increase telomerase activity.

Astragalus membranaceus (Huangqi) is a medicinal herb used in traditional Chinese medicine for over 2000 years. It contains beneficial components such as polysaccharides, flavonoids, and saponins. Research suggests that Astragalus membranaceus extracts have antioxidant, anti-inflammatory, immunoregulatory, anticancer, and organ-protective effects and increase telomerase activity. This review focuses on its potential to extend lifespan, countering vascular and brain aging, and its anticancer properties. Understanding the mechanisms of Astragalus membranaceus could lead to the development of effective and targeted therapeutic agents against aging (112).
Zinc is essential for immune efficiency, metabolic homeostasis, and antioxidant activity.

This review discusses the role of zinc in human health, aging, and immunosenescence. Zinc is an essential trace element involved in various cellular functions, including immune response. Zinc deficiency, common in older individuals, contributes to oxidative inflammatory aging and immunosenescence. The potential benefits of zinc supplementation for immune function are explored. The review summarizes recent findings on zinc's role, focusing on its impact on aging and immunosenescence (107).
Chondroitin sulfate can potentially become a geroprotective strategy to promote health during human aging.

Chondroitin sulfate has emerged as a potential geroprotective compound through in-silico and lifespan screens in model organisms. It is a glycosaminoglycan naturally produced in our body, attached to extracellular matrix proteins. Oral supplementation of chondroitin sulfate is well-tolerated in humans, exhibits favorable pharmacokinetics, correlates with healthy longevity, and has shown efficacy in reducing age-related diseases in clinical trials. A recent study demonstrated that chondroitin sulfate supplementation extends the lifespan of C. elegans worm. Therefore, chondroitin sulfate can potentially be a geroprotective strategy for promoting health during human aging. This review focuses on two potential mechanisms of action, maintaining extracellular matrix homeostasis and inhibiting inflammation, which contributes to countering age-related pathologies with chondroitin sulfate supplementation (119).
Oleuropein, unexpected benefits!

The study suggests that Oleuropein, a compound found in olive oil and olive leaves, offers a range of health benefits. It is a key part of the Mediterranean diet and is known for its antioxidant and anti-inflammatory effects. The study indicates that Oleuropein can effectively lower blood pressure, which may be beneficial in the treatment of hypertension. It also suggests potential protective roles against heart disease and neurodegenerative disorders like Parkinson’s and Alzheimer’s diseases, primarily by preventing the buildup of harmful proteins in the brain (69).
Polyphenols like oleuropein are the therapeutic agents of olive oil

The study highlights the significant health benefits of olive oil, particularly focusing on its content of polyphenols like oleuropein and hydroxytyrosol. These compounds are key to olive oil's antioxidant and anti-inflammatory effects, which contribute to its various health benefits. Olive oil, rich in these polyphenols, has been linked to improvements in heart health by enhancing endothelial function and optimizing lipid profiles. Additionally, it plays a role in preventing and managing several non-communicable diseases, including obesity, diabetes, cardiovascular diseases, and neurodegenerative disorders. The study underscores that these benefits are largely attributed to the synergistic effects of olive oil's complex nutritional composition, especially its high content of polyphenols like oleuropein and hydroxytyrosol (70).
Inhibitory effect of astaxanthin on oxidative stress-induced mitochondrial dysfunction-a mini-review

The review focuses on the role of astaxanthin, a red-colored carotenoid, in combating oxidative stress, a key factor in the development of various diseases and the aging process. Oxidative stress damages cells by disrupting mitochondrial function, which can lead to an excess of harmful reactive oxygen species and even cell death. Astaxanthin has been found to have strong anti-oxidative and anti-inflammatory effects on different cell types. By maintaining mitochondrial integrity, astaxanthin helps to counteract the damage caused by oxidative stress, thus potentially preventing or slowing the progression of diseases related to mitochondrial dysfunction (71)
Astaxanthin: A potential mitochondrial-targeted antioxidant treatment in diseases and with aging

The study concludes that astaxanthin, a powerful antioxidant, is gaining recognition for its ability to combat oxidative stress-related and aging diseases. It has been shown to lower plasma glucose and insulin levels, enhance overall body insulin sensitivity, and improve insulin-stimulated glucose uptake, acting as an insulin sensitizer. Additionally, astaxanthin has demonstrated benefits in improving muscle atrophy due to disuse, offering neuroprotective advantages, and preventing the aging effects on the skin caused by photoaging (72).
Pterostilbene: Sources, Metabolism, Health Promotion Effects, And Superiority to Resveratrol

The study highlights how Pterostilbene (PTS), predominantly found in blueberries, has emerged as a promising compound with various health benefits. Compared to resveratrol, PTS offers better intestinal absorption and greater stability in the liver. The studies reviewed indicate that PTS is effective in affecting multiple age-related diseases. Additionally, PTS has been found to have a higher bioavailability and lower toxicity than other similar compounds, making it a compelling option for dietary supplementation and therapeutic applications (73).
Chondroitin Sulfate as a Potential Longevity Pill

The study identifies chondroitin sulfate as a potential "geroprotector" - a compound that promotes health during aging and helps in slowing down age-related diseases. Chondroitin sulfate is a naturally occurring substance in the body, known for its role in maintaining the extracellular matrix, which is crucial for tissue health. The study found that oral supplementation of chondroitin sulfate is well-tolerated in humans and has a positive correlation with increased longevity and effectiveness in reducing age-related diseases. In experiments with the model organism C. elegans, supplementation of chondroitin sulfate increased lifespan, supporting its potential as a geroprotective strategy. The study suggests that chondroitin sulfate works through two primary mechanisms: maintaining extracellular matrix homeostasis and reducing inflammation, both of which are key factors in counteracting age-related pathologies (119)
Apigenin and NAD+

The study investigates the role of the flavonoid apigenin, found in various plants, in treating metabolic syndrome, a growing health concern worldwide. It focuses on how manipulating NAD+ metabolism can help manage this condition. The study reveals that CD38, a primary enzyme in mammals, plays a crucial role in regulating NAD+ levels and, consequently, sirtuin activity and global protein acetylation. By inhibiting CD38 using apigenin, the research demonstrates a significant increase in cellular NAD+ levels. This increase leads to reduced global protein acetylation, including in key proteins like p53 and RelA-p65. In experiments with obese mice, apigenin administration resulted in increased NAD+ levels, decreased protein acetylation, and notable improvements in glucose and lipid homeostasis. These findings suggest that targeting CD38 with apigenin offers a promising therapeutic approach for treating metabolic diseases through NAD+-dependent pathways (121).

Our standards

GMP certified

Manufactured in facilities that follow Good Manufacturing Practices (GMP), ensuring the highest quality and purity.

Scientist Approved

Formulated by experts and rigorously evaluated by scientists to ensure effectiveness and safety.

Clinical-Grade Dosage

Contains the precise dosages used in clinical studies, ensuring you receive the optimal amount for maximum benefit.

Made in the USA

Proudly produced in the USA, ensuring adherence to the highest standards of quality and safety.

Third-Party Tested

Every batch is independently tested by third-party labs to verify potency, purity, and safety.

Superior Bioavailability

Engineered for enhanced absorption, ensuring that your body can effectively utilize each nutrient.

One-Time Purchase

Receive a pouch filled with a one month supply of any product

Subscribe to unlock VIP benefits

Your welcome kit includes a free storage canister to store your monthly delivery. 100% metal and recyclable, for you, and for the planet

+ Free coaching and scientific guidance, delivered straight to your inbox

+ Up to 30% off subscriptions, cancel anytime

+ White glove, subscribers-only access to the team for questions on your longevity protocol

+ Constantly updated formulas that track the latest science, so you don’t have to

+ First in line benefits for new products, special discounts, and features

Here's what our customers say

Feeling unstoppable

I forgot what it felt like to feel energized. I was so overrun with fatigue for many years that I just got used to it but once I started taking Jung, I began to feel more alert, have stronger performance both mentally and physically, and my mood elevated as well. In the gym, I was instantly able to lift more weights and feel that I was able to perform sprints more easily. I recover more quickly from the hard training that I do and overall, I feel fantastic!

Brigette R.

Verified Jung Customer
Youth in a pill

Makes me feel amazing!

Megan L.

Verified Jung Customer
I feel like I have gotten younger

I simply feel like I have more energy to do everything. This is like a caffeine jolt without any of the side effects. I am hoping these results continue and build on what is currently happening? I'm willing to continue for a couple of months to find out.

Kathryn C.

Verified Jung Customer

FAQ’s

Can I use it as a replacement for my multivitamin supplement?

No - Longevity Foundation is not a replacement for your daily multivitamin. Longevity Foundation is designed to target aging - it is not formulated to supplement a broad nutritional profile. You could take them together with prior consultation with your physician.
When will I see the first effects?

Some users report feeling more energetic after only a few days. Most users report seeing or feeling a noticeable benefit within 30-60 days. However, like all longevity protocols, the effects amplify and compound with time.
I'm feeling lazy. Can I take both AM + PM pills at once?

Absolutely. There is absolutely no harm in taking AM + PM simultaneously, and you can still achieve the lion's share of benefits. In fact, they were originally conceived as a single pill. However, to enhance efficacy and precision, we still suggest taking them separately as they are designed to coincide with separate internal mechanisms, which are more active during the day or night.
I forgot yesterday's dose. Should I take double the dose the next day?

Taking double doses is not recommended.
Is this supplement all I need to live a longer, healthy life?

No. Longevity Foundation greatly supports longevity, but it is only one part of a longevity lifestyle. This supplement is not a replacement for a healthy, balanced diet and evidence-based lifestyle choices like quality sleep, exercise, stress control, and mindful blood sugar balance.
I'm pregnant! Can I continue taking the supplement?

First of all - congrats! But unfortunately, its best not to. While there are no known issues with the ingredients in our Longevity Foundation for pregnant women, we suggest you quit taking the supplement during the course of pregnancy as well as breastfeeding. There is not enough available evidence on the impact of the supplement components on a pregnant or nursing mother.
I heard resveratrol is great for slowing aging - why didn't you include this?

It is due to the inconclusive results of numerous studies on resveratrol, its apparent limited bioavailability in humans, and many results that contradict each other. Science is constantly changing, and we follow the science. If more conclusive data emerges, we will include it in future iterations. Therefore, we use pterostilbene, which has features similar to resveratrol but has been proven more bioavailable and easier to absorb.
I hear NMN is great for aging - why didn't you include this?

NMN is a NAD(+) donor; the same is NR or niacin (in our formula). Nevertheless, NMN is still in the middle of emerging research, while niacin has been thoroughly tested in humans for decades, with a much broader set of whole-body benefits (which is why we included niacin in our supplement). We also added Flavonoid like apigenin and quercetin formula for a potential synergistic effect with NAD+. Apigenin inhibits the activity of CD38, which consumes NAD+. It increases the amount of NAD+ not by supplying it but by inhibiting its degradation (83). You can still take an additional separate NAD+ booster, however, its best to consult with a doctor when combining supplements. However, note that decreased NAD+ levels are only a single hallmark of aging and deterioration, therefore, having a balanced portfolio of interventions that considers all hallmarks and lifestyle choices collectively, is the most effective approach.
Why are the doses divided into morning and evening formulas?

The division of doses allows for optimized nutrient absorption and potential timing considerations based on ingredient properties. It may also facilitate compliance by incorporating supplementation into a daily routine. For example the AM formula is unlikely to break a fast and has ingredients that are water soluble, so its designed to be taken when many engage in intermittent fasting practices, while the PM formula includes ingredients that are more readily absorbed with oil (oil soluble), at night, when people are more likely to have evening meals to help carry the absorption of certain compounds.
I've heard of other longevity compounds. Why did you put them in other Jung+ formulas and not this?

Because every ingredient you put in your body has multiple effects, and its not great practice to just take whatever, whenever. In many cases, certain longevity ingredients have dual effects - such as Glycine in our Advanced Sleep Repair formula, which has been shown to significantly benefit sleep. And some popular longevity ingredients should be taken during specific times, like Berberine in our Glucose Blocker, which helps module blood sugar levels, and is much safer taken by healthy individuals alongside sugar or carb rich foods to avoid hypoglycemia. Longevity Foundation is designed to be taken as a standalone product, without a specific lifestyle prompt. The rest of our product line focuses on activating behavioral modifications or utilizing particular longevity levers. For maximum impact, we have engineered formulas with specific ingredients that would help amplify and strengthen a certain lifestyle or behavior.

Developed by experts

Dr. Sagner is a world leading human performance specialist, sports and preventive medicine, and was the medical director at Europe’s first University medical center section for preventive medicine and lifestyle medicine. Dr Sagner is a member of the European Union Platform for Action on Diet, Physical Activity and Health and a partner of the European Innovation Partnership on Active and Healthy Aging.

Dr. Michael Sagner, MD

FRSM, FRCP, FESPM | University of Oxford

Francois-Xavier Pellay, PhD, known as the 'Longevity Molecule Hunter', is a world leading scientist and entrepreneur in the longevity industry. Pellay is a multidisciplinary scientist with a background which includes a Master's degree in Biochemistry, a Master's degree in Organic Chemistry, a Ph.D. in Bioinformatics and years of expertise in Microbiology, Molecular Biology, Cellular Biology and Biology of Aging.

Francois-Xavier Pellay, PhD

Physician-scientist | Postdoctoral Fellow | University of Oxford

Dr. Fady Hannah-Shmouni, MD FRCPC, is a physician-investor at the forefront of endocrinology, genomics, and healthspan medicine. As a distinguished Professor at the University of British Columbia, he passionately empowers individuals by facilitating access to groundbreaking technologies in precision medicine, including artificial intelligence and genomic advancements.

Dr. Fady Hannah-Shmouni

MD FRCPC, a physician-investor at the forefront of endocrinology, genomics, and healthspan medicine

Dr. Avi Roy is an accomplished biomedical scientist, mentor, and entrepreneur with a deep-rooted passion for advancing the field of longevity. His academic journey culminated in a PhD from the University of Oxford. With over 15 years of dedicated research and development in the longevity sector, Dr. Roy has established himself as a a leading figure in this dynamic and ever-evolving field. As a mentor and investor in health-tech startups, he continues to inspire and guide the next generation of scientists and entrepreneurs.

Avi Roy

Biomedical Scientist | Inventor | University of Oxford | Founder, UDA

100% Money Back Guarantee

At Jung, we believe in the power of our products and want you to feel confident in your purchase. That’s why we’ve partnered with Onward to offer an unmatched money-back guarantee. With Onward VIP Protection, your purchase is covered by a full money-back guarantee. If you’re not completely satisfied, simply return the product for a hassle-free refund.

100% Money Back Guarantee

with

References

Reference link
1. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194-217.
Reference link
2. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023;186(2):243-78.
Reference link
3. Lemoine M. The evolution of the hallmarks of aging. Frontiers in Genetics. 2021;12:693071.
Reference link
4. Sies H, Berndt C, Jones DP. Oxidative stress. Annual review of biochemistry. 2017;86:715-48.
Reference link
5. Krumova K, Cosa G. Overview of reactive oxygen species. 2016.
Reference link
6. Romano AD, Serviddio G, De Matthaeis A, Bellanti F, Vendemiale G. Oxidative stress and aging. Journal of nephrology. 2010;23:S29-36.
Reference link
7. Munro D, Pamenter ME. Comparative studies of mitochondrial reactive oxygen species in animal longevity: technical pitfalls and possibilities. Aging Cell. 2019;18(5):e13009.
Reference link
8. McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxidative medicine and cellular longevity. 2013;2013.
Reference link
9. Deepika, Maurya PK. Health Benefits of Quercetin in Age-Related Diseases. Molecules. 2022;27(8).
Reference link
10. Liu S, He L, Yao K. The antioxidative function of alpha-ketoglutarate and its applications. BioMed research international. 2018;2018.
Reference link
11. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxidants & redox signaling. 2013;19 2:151-62.
Reference link
12. Camera E, Mastrofrancesco A, Fabbri C, Daubrawa F, Picardo M, Sies H, et al. Astaxanthin, canthaxanthin and beta-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes. Experimental dermatology. 2009;18(3):222-31.
Reference link
13. Minois N. Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review. Gerontology. 2014;60(4):319-26.
Reference link
14. Kim M, Jung J, Jeong NY, Chung H-J. The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes. Anatomical Science International. 2019;94(4):285-94.
Reference link
15. Borjan D, Leitgeb M, Knez Ž, Hrnčič MK. Microbiological and antioxidant activity of phenolic compounds in olive leaf extract. Molecules. 2020;25(24):5946.
Reference link
16. Li YR, Li S, Lin CC. Effect of resveratrol and pterostilbene on aging and longevity. Biofactors. 2018;44(1):69-82.
Reference link
17. Zhu X, Li N, Wang Y, Ding L, Chen H, Yu Y, et al. Protective effects of quercetin on UVB irradiation‑induced cytotoxicity through ROS clearance in keratinocyte cells. Oncology reports. 2017;37(1):209-18.
Reference link
18. Ng QX, De Deyn MLZQ, Loke W, Foo NX, Chan HW, Yeo WS. Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies. Journal of Dietary Supplements. 2021;18(2):169-82.
Reference link
19. da Silva AC, Paiva JP, Diniz RR, Dos Anjos VM, Silva ABS, Pinto AV, et al. Photoprotection assessment of olive (Olea europaea L.) leaves extract standardized to oleuropein: In vitro and in silico approach for improved sunscreens. Journal of Photochemistry and Photobiology B: Biology. 2019;193:162-71.
Reference link
20. Lin PH, Sermersheim M, Li H, Lee PHU, Steinberg SM, Ma J. Zinc in Wound Healing Modulation. Nutrients. 2017;10(1).
Reference link
21. Schwartz JR, Marsh RG, Draelos ZD. Zinc and skin health: overview of physiology and pharmacology. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al]. 2005;31(7 Pt 2):837-47; discussion 47.
Reference link
22. Mehraein F, Sarbishegi M, Aslani A. Evaluation of effect of oleuropein on skin wound healing in aged male BALB/c mice. Cell Journal (Yakhteh). 2014;16(1):25.
Reference link
23. Oliveira AL, Gondim S, Gómez-García R, Ribeiro T, Pintado M. Olive leaf phenolic extract from two Portuguese cultivars–bioactivities for potential food and cosmetic application. Journal of Environmental Chemical Engineering. 2021;9(5):106175.
Reference link
24. Yoon JH, Kim MY, Cho JY. Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer. Int J Mol Sci. 2023;24(2).
Reference link
25. Zhang Y, Wang J, Cheng X, Yi B, Zhang X, Li Q. Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway. European journal of histochemistry : EJH. 2015;59(2):2467.
Reference link
26. Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009;11(11):1305-14.
Reference link
27. Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy. 2019;15(1):165-8.
Reference link
28. Guo H, Ding H, Tang X, Liang M, Li S, Zhang J, et al. Quercetin induces pro-apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro. Thoracic cancer. 2021;12(9):1415-22.
Reference link
29. Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, et al. Senolytics improve physical function and increase lifespan in old age. Nature Medicine. 2018;24(8):1246-56.
Reference link
30. Chen RJ, Lee YH, Yeh YL, Wu WS, Ho CT, Li CY, et al. Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases. Journal of food and drug analysis. 2017;25(1):125-33.
Reference link
31. Rigacci S, Miceli C, Nediani C, Berti A, Cascella R, Pantano D, et al. Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight. Oncotarget. 2015;6(34):35344.
Reference link
32. Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and disease. Science. 2018;359(6374).
Reference link
33. Mijaljica D, Prescott M, Devenish RJ. The intriguing life of autophagosomes. Int J Mol Sci. 2012;13(3):3618-35.
Reference link
34. Stewart LK, Soileau JL, Ribnicky D, Wang ZQ, Raskin I, Poulev A, et al. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism: clinical and experimental. 2008;57(7 Suppl 1):S39-46.
Reference link
35. Gasperi V, Sibilano M, Savini I, Catani MV. Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications. Int J Mol Sci. 2019;20(4).
Reference link
36. Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020;12(1).
Reference link
37. Makarov MV, Trammell SAJ, Migaud ME. The chemistry of the vitamin B3 metabolome. Biochem Soc Trans. 2019;47(1):131-47.
Reference link
38. Morris MC, Evans DA, Bienias JL, Scherr PA, Tangney CC, Hebert LE, et al. Dietary niacin and the risk of incident Alzheimer’s disease and of cognitive decline. Journal of Neurology, Neurosurgery & Psychiatry. 2004;75(8):1093-9.
Reference link
39. Sorrenti V, Davinelli S, Scapagnini G, Willcox BJ, Allsopp RC, Willcox DC. Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging. Mar Drugs. 2020;18(7).
Reference link
40. Gupta VK, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans TS, et al. Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat Neurosci. 2013;16(10):1453-60.
Reference link
41. Romero-Márquez JM, Navarro-Hortal MD, Forbes-Hernández TY, Varela-López A, Puentes JG, Pino-García RD, et al. Exploring the Antioxidant, Neuroprotective, and Anti-Inflammatory Potential of Olive Leaf Extracts from Spain, Portugal, Greece, and Italy. Antioxidants. 2023;12(8):1538.
Reference link
42. Salehi B, Venditti A, Sharifi-Rad M, Kręgiel D, Sharifi-Rad J, Durazzo A, et al. The Therapeutic Potential of Apigenin. Int J Mol Sci. 2019;20(6).
Reference link
43. Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA. The rate of increase of short telomeres predicts longevity in mammals. Cell Rep. 2012;2(4):732-7.
Reference link
44. Xu K, Guo Y, Li Z, Wang Z. Aging Biomarkers and Novel Targets for Anti-Aging Interventions. Adv Exp Med Biol. 2019;1178:39-56.
Reference link
45. Aguiar SS, Rosa TS, Neves RVP, Leite PLA, Maciel LA, Gutierrez SD, et al. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? Int J Sports Med. 2022;43(1):29-33.
Reference link
46. Guinobert I, Blondeau C, Colicchio B, Oudrhiri N, Dieterlen A, Jeandidier E, et al. The Use of Natural Agents to Counteract Telomere Shortening: Effects of a Multi-Component Extract of Astragalus mongholicus Bunge and Danazol. Biomedicines. 2020;8(2).
Reference link
47. Wirth A, Wolf B, Huang CK, Glage S, Hofer SJ, Bankstahl M, et al. Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length. Geroscience. 2021;43(2):673-90.
Reference link
48. Carding S, Verbeke K, Vipond DT, Corfe BM, Owen LJ. Dysbiosis of the gut microbiota in disease. Microbial ecology in health and disease. 2015;26(1):26191.
Reference link
49. Karunaratne TB, Okereke C, Seamon M, Purohit S, Wakade C, Sharma A. Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease. Nutrients. 2020;13(1).
Reference link
50. Magnúsdóttir S, Ravcheev D, de Crécy-Lagard V, Thiele I. Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes. Frontiers in Genetics. 2015;6.
Reference link
51. Etxeberria U, Arias N, Boqué N, Macarulla MT, Portillo MP, Martínez JA, et al. Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats. J Nutr Biochem. 2015;26(6):651-60.
Reference link
52. Murota K, Nakamura Y, Uehara M. Flavonoid metabolism: the interaction of metabolites and gut microbiota. Bioscience, Biotechnology, and Biochemistry. 2018;82(4):600-10.
Reference link
53. Niechcial A, Schwarzfischer M, Wawrzyniak M, Atrott K, Laimbacher A, Morsy Y, et al. Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis. Journal of Crohn's and Colitis. 2023;17(9):1489-503.
Reference link
54. Zhao HM, Wang Y, Huang XY, Huang MF, Xu R, Yue HY, et al. Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer's patches. World journal of gastroenterology. 2016;22(11):3175-85.
Reference link
55. Song Q, Cheng SW, Li D, Cheng H, Lai YS, Han Q, et al. Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db/db mice. Front Pharmacol. 2022;13:1043527.
Reference link
56. Cai X, Yuan Y, Liao Z, Xing K, Zhu C, Xu Y, et al. α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway. Faseb J. 2018;32(1):488-99.
Reference link
57. Pirinen E, Auranen M, Khan NA, Brilhante V, Urho N, Pessia A, et al. Niacin Cures Systemic NAD(+) Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy. Cell Metab. 2020;31(6):1078-90.e5.
Reference link
58. Gaia G, Anna W, Flavien B, Eugenia M, Benjamin B, Guillaume EJ, et al. Mitochondrial Calcium Uptake Declines during Aging and is Directly Activated by Oleuropein to Boost Energy Metabolism and Skeletal Muscle Performance. bioRxiv. 2023:2023.02.24.529830.
Reference link
59. Van Dronkelaar C, van Velzen A, Abdelrazek M, van der Steen A, Weijs PJ, Tieland M. Minerals and sarcopenia; the role of calcium, iron, magnesium, phosphorus, potassium, selenium, sodium, and zinc on muscle mass, muscle strength, and physical performance in older adults: a systematic review. Journal of the American Medical Directors Association. 2018;19(1):6-11. e3.
Reference link
60. Katta J, Jin Z, Ingham E, Fisher J. Chondroitin sulphate: an effective joint lubricant? Osteoarthritis and cartilage. 2009;17(8):1001-8.
Reference link
61. Maresca M, Micheli L, Cinci L, Bilia AR, Ghelardini C, Di Cesare Mannelli L. Pain relieving and protective effects of Astragalus hydroalcoholic extract in rat arthritis models. Journal of Pharmacy and Pharmacology. 2017;69(12):1858-70.
Reference link
62. Goodpaster BH, Sparks LM. Metabolic Flexibility in Health and Disease. Cell Metabolism. 2017;25(5):1027-36.
Reference link
63. Smith RL, Soeters MR, Wüst RCI, Houtkooper RH. Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease. Endocrine reviews. 2018;39(4):489-517.
Reference link
64. Sebastián D, Acín-Pérez R, Morino K. Mitochondrial Health in Aging and Age-Related Metabolic Disease. Oxidative Medicine and Cellular Longevity. 2016;2016:5831538.
Reference link
65. Starkov AA. An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress. Molecular and Cellular Neuroscience. 2013;55:13-6.
Reference link
66. Palikaras K, Princz A, Tavernarakis N. Mitophagy modulators. Encyclopedia of Biomedical Gerontology. 2018;2:433-46.
Reference link
67. Zhang Y, Bai J, Cui Z, Li Y, Gao Q, Miao Y, et al. Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging. Nature Aging. 2023:1-15.
Reference link
68. Qabaha K, Al-Rimawi F, Qasem A, Naser SA. Oleuropein is responsible for the major anti-inflammatory effects of olive leaf extract. Journal of medicinal food. 2018;21(3):302-5.
Reference link
69. Sun W, Frost B, Liu J. Oleuropein, unexpected benefits! Oncotarget. 2017;8(11):17409.
Reference link
70. Isaakidis A, Maghariki JE, Carvalho-Barros S, Gomes AM, Correia M. Is there more to olive oil than healthy lipids? Nutrients. 2023;15(16):3625.
Reference link
71. Kim SH, Kim H. Inhibitory effect of astaxanthin on oxidative stress-induced mitochondrial dysfunction-a mini-review. Nutrients. 2018;10(9):1137.
Reference link
72. Sztretye M, Dienes B, Gönczi M, Czirják T, Csernoch L, Dux L, et al. Astaxanthin: A potential mitochondrial-targeted antioxidant treatment in diseases and with aging. Oxidative Medicine and Cellular Longevity. 2019;2019.
Reference link
73. Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Molecules. 2022;27(19).
Reference link
74. Lin W-S, Leland JV, Ho C-T, Pan M-H. Occurrence, bioavailability, anti-inflammatory, and anticancer effects of pterostilbene. Journal of Agricultural and Food Chemistry. 2020;68(46):12788-99.
Reference link
75. Poljsak B, Milisav I. NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair, Longevity, and Health Span. Rejuvenation Res. 2016;19(5):406-15.
Reference link
76. Aman Y, Qiu Y, Tao J, Fang EF. Therapeutic potential of boosting NAD+ in aging and age-related diseases. Translational Medicine of Aging. 2018;2:30-7.
Reference link
77. Schultz MB, Sinclair DA. Why NAD+ declines during aging: it’s destroyed. Cell metabolism. 2016;23(6):965-6.
Reference link
78. Oblong JE. The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging. DNA repair. 2014;23:59-63.
Reference link
79. Ross J. Niacin: More Than Anti-Aging.
Reference link
80. Poljsak B, Milisav I. Vitamin B3 forms as precursors to NAD+: Are they safe? Trends in Food Science & Technology. 2018;79:198-203.
Reference link
81. Freeberg KA, Udovich CAC, Martens CR, Seals DR, Craighead DH. Dietary supplementation with NAD+-boosting compounds in humans: Current knowledge and future directions. The Journals of Gerontology: Series A. 2023:glad106.
Reference link
82. Imai S-i, Yoshino J. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes, Obesity and Metabolism. 2013;15(s3):26-33.
Reference link
83. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, et al. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013;62(4):1084-93.
Reference link
84. Strauss E. Longevity research. Single signal unites treatments that prolong life. Science. 2003;300(5621):881-3.
Reference link
85. Keenan JM. Wax-matrix extended-release niacin vs inositol hexanicotinate: A comparison of wax-matrix, extended-release niacin to inositol hexanicotinate “no-flush” niacin in persons with mild to moderate dyslipidemia. Journal of Clinical Lipidology. 2013;7(1):14-23.
Reference link
86. Lombard DB, Kohler WJ, Guo AH, Gendron C, Han M, Ding W, et al. High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv. 2020;6(40).
Reference link
87. Kumar R, Vijayalakshmi S, Nadanasabapathi S. Health Benefits of Quercetin. life science journal. 2017;2:142-51.
Reference link
88. Kampkötter A, Timpel C, Zurawski RF, Ruhl S, Chovolou Y, Proksch P, et al. Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comparative biochemistry and physiology Part B, Biochemistry & molecular biology. 2008;149(2):314-23.
Reference link
89. Gyanwali B, Lim ZX, Soh J, Lim C, Guan SP, Goh J, et al. Alpha-Ketoglutarate dietary supplementation to improve health in humans. Trends Endocrinol Metab. 2022;33(2):136-46.
Reference link
90. Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32(3):447-56 e6.
Reference link
91. Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, et al. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021;13(22):24485-99.
Reference link
92. Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, et al. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015;22(3):508-15.
Reference link
93. https://pubmed.ncbi.nlm.nih.gov/32112672/
Reference link
94. Sun Y, Qin H, Zhang H, Feng X, Yang L, Hou DX, et al. Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells. Food & nutrition research. 2021;65.
Reference link
95. Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28.
Reference link
96. Jung CH, Kim H, Ahn J, Jeon T-I, Lee DH, Ha TY. Fisetin regulates obesity by targeting mTORC1 signaling. The Journal of nutritional biochemistry. 2013;24 8:1547-54.
Reference link
97. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004;430(7000):686-9.
Reference link
98. Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, et al. Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American Journal of Clinical Nutrition. 2018;108(2):371-80.
Reference link
99. Raj SD, Fann DY, Wong E, Kennedy BK. Natural products as geroprotectors: An autophagy perspective. Med Res Rev. 2021.
Reference link
100. Yue F, Li W, Zou J, Jiang X, Xu G, Huang H, et al. Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy. Cancer research. 2017;77(11):2938-51.
Reference link
101. Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011;16(4):355-64.
Reference link
102. Tominaga K, Hongo N, Karato M, Yamashita E. Cosmetic benefits of astaxanthin on humans subjects. Acta biochimica Polonica. 2012;59(1):43-7.
Reference link
103. Fakhri S, Aneva IY, Farzaei MH, Sobarzo-Sánchez E. The Neuroprotective Effects of Astaxanthin: Therapeutic Targets and Clinical Perspective. Molecules. 2019;24(14).
Reference link
104. Yazaki K, Yoshikoshi C, Oshiro S, Yanase S. Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans. Oxid Med Cell Longev. 2011;2011:596240.
Reference link
105. Hajianfar H, Mollaghasemi N, Tavakoly R, Campbell MS, Mohtashamrad M, Arab A. The association between dietary zinc intake and health status, including mental health and sleep quality, among Iranian female students. Biological Trace Element Research. 2021;199:1754-61.
Reference link
106. Hernández-Camacho JD, Vicente-García C, Parsons DS, Navas-Enamorado I. Zinc at the crossroads of exercise and proteostasis. Redox biology. 2020;35:101529.
Reference link
107. Cabrera Á J. Zinc, aging, and immunosenescence: an overview. Pathobiology of aging & age related diseases. 2015;5:25592.
Reference link
108. Cherasse Y, Urade Y. Dietary Zinc Acts as a Sleep Modulator. Int J Mol Sci. 2017;18(11).
Reference link
109. Rondanelli M, Opizzi A, Monteferrario F, Antoniello N, Manni R, Klersy C. The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J Am Geriatr Soc. 2011;59(1):82-90.
Reference link
110. Wanitphakdeedecha R, Ng JNC, Junsuwan N, Phaitoonwattanakij S, Phothong W, Eimpunth S, et al. Efficacy of olive leaf extract–containing cream for facial rejuvenation: A pilot study. Journal of Cosmetic Dermatology. 2020;19(7):1662-6.
Reference link
111. Dominguez RB, Tupone MG, Catanesi M, Castelli V, d’Angelo M, Antonosante A, et al. Pro‐oxidant and pro‐apoptotic effects of Olive leaf extract on Cancers of Female Reproductive tissues. The FASEB Journal. 2020;34(S1):1-.
Reference link
112. Ping L, Haiping Z, Yumin L. Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic. Aging and Disease. 2017;8:868-86.
Reference link
113. Ionkova I, Momekov G, Proksch P. Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets. Fitoterapia. 2010.
Reference link
114. Shetty AK, Kodali M, Upadhya R, Madhu LN. Emerging Anti-Aging Strategies - Scientific Basis and Efficacy. Aging Dis. 2018;9(6):1165-84.
Reference link
115. Zhang H, Pan N, Xiong S, Zou S, Li H, Xiao L, et al. Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J. 2012;441(1):417-24.
Reference link
116. Ronca F, Palmieri L, Panicucci P, Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis and Cartilage. 1998;6:14-21.
Reference link
117. Shavlovskaya O, Zolotovskaya I, Prokofyeva YS. Anti-inflammatory and anti-aging effects of chondroitin sulfate. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(5):111-6.
Reference link
118. Pichert A, Samsonov SA, Theisgen S, Thomas L, Baumann L, Schiller J, et al. Characterization of the interaction of interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated derivatives by spectroscopy and molecular modeling. Glycobiology. 2012;22(1):134-45.
Reference link
119. Ewald CY. Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill. Frontiers in aging. 2021;2:741843.
Reference link
120. Miller KL, Clegg DO. Glucosamine and chondroitin sulfate. Rheumatic Disease Clinics. 2011;37(1):103-18.
Reference link
121. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, et al. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013;62(4):1084-93.
Reference link
122. Jasar D, Kubelka-Sabit K, Curcik-Trajkovska B, Filipovski V. Vitamin B3 dietary intake and its role in aging. Journal of Hygienic Engineering and Design. 2015;13:90-3.
Reference link
123. Zheng S-Y, Li Y, Jiang D, Zhao J, Ge J-F. Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A-549. Mol Med Rep. 2012;5(3):822-6.
Reference link
124. González-Hedström D, García-Villalón ÁL, Amor S, de la Fuente-Fernandez M, Almodóvar P, Prodanov M, et al. Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats. Sci Rep-Uk. 2021;11(1):8188.
Reference link
125. Oyebode OT, Abolaji AO, Oluwadare JO, Adedara AO, Olorunsogo OO. Apigenin ameliorates D-galactose-induced lifespan shortening effects via antioxidative activity and inhibition of mitochondrial-dependent apoptosis in Drosophila melanogaster. Journal of Functional Foods. 2020;69:103957.

Not sure where to start? Build your custom protocol today.

TAKE THE QUIZ

Master formula

Longevity boosters

Test & track

Save!

ALL

MASTER FORMULA

LONGEVITY BOOSTERS

SAVE

Longevity Foundation

Advanced Sleep Repair

The 12 Hallmarks of Aging: What to Look For & Why They Matter

Essential Supplements for Healthy Aging & Longevity

Longevity Foundation

Subscribe, Bundle, and Enjoy the Works

As seen in

Two powerful formulas, one complete longevity regimen

Why it’s different

Targets All 12 Hallmarks Of Aging

Younger Skin From Within

Multi-Modal Cellular Clean-up

Enhanced Cognition

Synergistically Boost NAD+

Strengthen Muscles, Nourish Joints

Improved Cellular Energy & Vitality

Shield Cells From Oxidative Stress

Fortify Immunity, Target 'Inflammaging'

Supports Telomerase Activity

Improved Gut Microbiome Balance

How to use

+ behavioral protocol

+ Warning

Look inside

AM - Niacin

200 mg

AM - Pterostilbene

100 mg

AM - Quercetin

200 mg

AM - Calcium Alpha-Ketoglutarate

1,000 mg

AM - Fisetin

50 mg

AM - Astaxanthin

3.5 mg

PM - Spermidine

2.5 mg

PM - Zinc

10 mg

PM - Oleuropein (Olive Leaf Extract)

650 mg

PM - Astragalus

100 mg

PM - Chondroitin

700 mg

PM - Apigenin

50 mg

What are the 12 hallmarks of aging, how can they be addressed?

Scientific studiеs

Niacin is a precursor for the coenzyme NAD+.

Fisetin is a senotherapeutic that might extend health and lifespan

Pterostilbene has become an attractive drug candidate for treating several disease conditions.

Induction of autophagy by spermidine promotes longevity

Quercetin causes apoptosis in the A-549 lung cancer cell lines.

Higher spermidine intake is linked to lower mortality

Alpha-ketoglutarate may extend human healthspan.

Astaxanthin can modulate Nrf2, FOXO3, Sirt1, and Klotho proteins linked to longevity.

Supplementation with olive leaf extract ameliorates age-related vascular and metabolic changes in Wistar rats.

The extract component of Astragalus membranaceus can increase telomerase activity.

Zinc is essential for immune efficiency, metabolic homeostasis, and antioxidant activity.

Chondroitin sulfate can potentially become a geroprotective strategy to promote health during human aging.

Oleuropein, unexpected benefits!

Polyphenols like oleuropein are the therapeutic agents of olive oil

Inhibitory effect of astaxanthin on oxidative stress-induced mitochondrial dysfunction-a mini-review

Astaxanthin: A potential mitochondrial-targeted antioxidant treatment in diseases and with aging

Pterostilbene: Sources, Metabolism, Health Promotion Effects, And Superiority to Resveratrol

Chondroitin Sulfate as a Potential Longevity Pill

Apigenin and NAD+

Your personal longevity kit, engineered for life

One-Time Purchase

Subscribe to unlock VIP benefits