Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal
Cellular Skin Renewal

Cellular Skin Renewal

Cellular Skin Renewal transcends the limitations of topical creams or serums, standing alone as the only skin supplement leveraging the cutting-edge advancements of longevity science to combat every major aspect of biological skin aging from the inside out. Precision engineered using frontline longevity science, it's a complete protocol that targets the multifaceted drivers of skin aging, helping to bolster cells and capillaries, clear our senescent zombie cells, stimulate NAD+, collagen and hyaluronic acid production, neutralize aging accelerators like Advanced Glycation End Products (AGEs) from eating sugar, and more. This groundbreaking formula serves as a personal longevity clinician, designed to reduce wrinkles, improve elasticity, and balance skin tone and texture by correcting the things that cause them. With its powerful blend of precursors, antioxidants, and longevity molecules, Cellular Skin Renewal goes beyond skincare —it's a testament to the pinnacle of longevity science and skin rejuvenation.

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Cellular Skin Renewal
Vitamin C (as ascorbic acid)
150 mg
Vitamin E (as dl-alpha-tocopheryl acetate)
30 mg
Niacin (as niacinamide)
500 mg
VERISOL® collagen peptides
2,500 mg
N-Acetyl-D-Glucosamine (NAG)
500 mg
Hyaluronic acid (as sodium hyaluronate)
150 mg
CeraLOK® rice ceramide powder
40 mg
AstaZine® Astaxanthin (from Haematococcus pluvialis algae extract)
3.5 mg
Spermidine HCl
1 mg

Target every hallmark of skin aging, in a single protocol

Precision engineered dermal longevity protocol, from the inside out.

Why it’s different

  • Revolutionizing Collagen Production

    For Enhanced Thickness, Firmness, and Elasticity

    The role of collagen in skin health is no secret. However, few know that collagen comes in different shapes in sizes, each with a distinct role in the body - skin collagen is just one type (1, 2). Unfortunately, most collagen supplements fall short in impacting skin at all, being broken down into normal amino acids (protein) used for general bodily functions, not specifically collagen production in the skin (3-5).

    Cellular Skin Renewal revolutionizes this process. It incorporates VERISOL®, a patented bioactive collagen peptide which has actually been proven to enhance skin elasticity, reduce wrinkles, and improve skin structure in human trials. VERISOL® operates uniquely, mimicking damaged collagen fragments. These signal fibroblasts, the skin's collagen-producing cells, to produce more collagen to replace the 'damaged' ones. Even cellulite, a problem often addressed ineffectively by targeting excessive fat or microcirculation/drainage, has been shown to decrease with VERISOL® (6). Our synergistic approach bolsters and reinforces the work of our peptides for maximum collagen regeneration. Vitamin C, a crucial cofactor for the enzymes prolyl hydroxylase and lysyl hydroxylase, which stabilize the collagen molecule. Without vitamin C, collagen production is inefficient (7). Niacinamide further boosts collagen production, enhances skin texture, and strengthens your skin's natural defenses (8). Lastly, spermidine also aids in restoring skin structure by stimulating the production of collagen and vital lipids in aging skin cells (9).

  • Radical Hydration that Defies Wrinkles

    Boost Hyaluronic Acid Production From Within

    Hydration, crucial for reducing fine lines and wrinkles, starts from within - topical creams just block pores from letting moisture escape. Cellular Skin Renewal is engineered to optimize this internal process from the inside out.

    Hyaluronic acid (HA), nature's moisture magnet, is key to skin hydration, the cornerstone for maintaining plump, smooth, wrinkle-free skin (10, 11). Due to its molecular size, topical HA (found in serums and creams) falls short for this challenge, due to its inability to penetrate the skin, where it's needed.

    Cellular Skin Renewal tackles this problem by providing an oral dose of hyaluronic acid, while synergistically turbocharging your body's internal HA production. It employs N-Acetyl-D-glucosamine, a rare and potent HA precursor with remarkable bioavailability, promoting your body's inherent HA creation.

    To reinforce internal hydration with more rapid moisture, we’ve added powerful CeraLOK® oral ceramides, backed by multiple clinical studies to strengthen the skin's moisture barrier, prevent water loss, and promote youthful skin (12).

    Vitamin E adds to this hydration armor by locking in moisture, while collagen peptides augment the skin's water retention capacity for a smoother and more hydrated look (2, 13).

  • Boost NAD+ Production in Skin

    To Activate Cellular Energy

    Cellular Skin Renewal targets a pivotal aging challenge – declining NAD+ levels, crucial for skin cell vitality, and one of the fundamental drivers of aging. Enriched with niacinamide, a proven NAD+ precursor that bolsters NAD+ in skin cells. This enhancement is vital for DNA protection against UV damage and for activating sirtuins, proteins essential for longevity and skin health. NAD+ boosts cellular energy metabolism, DNA repair, and gene expression. Specifically, sirtuins like SIRT1 and SIRT3, rejuvenate skin by increasing collagen production, reducing oxidative stress, and balancing inflammation (14-16). By elevating NAD+ levels, Cellular Skin Renewal offers a robust, inside-out approach to reverse and prevent signs of skin aging, ensuring healthier, more resilient skin.

  • Purge Zombie Cells And Broken Proteins

    Clear Zombie Cells in Skin, For Whole Body Health

    Skin, the body's largest organ, is a primary battleground against senescent 'zombie' cells. These cells, key contributors to whole-body aging accumulate due to skin's extensive exposure to environmental damage (17, 18). Their presence accelerates the aging process, leading to uneven skin tone, rough texture, slower cell turnover, and reduced collagen production. More alarmingly, they exacerbate whole-body aging by releasing inflammatory proteins, impacting vital organs from your heart to your brain (19-21).

    Cellular Skin Renewal provides a portfolio of interventions against senescent cells that aims to not only prevent, but help clear them out. At the heart of our strategy is Spermidine, a naturally occurring polyamine renowned for its remarkable role in promoting autophagy. This process facilitates the removal of cellular debris, enhancing cell renewal, function and vitality, which is linked to a significant reduction in visible aging signs (22, 23). This aligns with research indicating spermidine's ability to modulate aging, suppress age-related diseases, and extend lifespan in model organisms, although the precise mechanisms continue to be explored.

    Complementing spermidine, the formula includes a blend of antioxidants, vitamin C and E, which synergistically form a defensive shield against oxidative stress, a key factor in cellular senescence (7, 24). Collagen peptides are another essential component, supporting the skin's extracellular matrix and mitigating the impact of senescent cells (5, 25).

    Lastly, niacinamide is strategically incorporated to enhance the skin's barrier function, creating a more resilient environment less susceptible to the effects of senescence (26).

  • Boost antioxidants defense

    A barrier for the barrier organ of your body

    Cellular Skin Renewal not only nurtures but also shields your skin, the body's primary defense barrier, from life's relentless wear and tear. The skin barrier is the frontline against environmental aggressors like pollution and UV rays (27, 28). As we age, maintaining the integrity of this barrier becomes increasingly vital, as it plays a key role in temperature regulation, wound healing, and pathogen defense. Our formula offers a precision blend of powerful antioxidants to reinforce this essential protective layer.

    Central to this blend is AstaZine® astaxanthin, often hailed as the king of antioxidants for its unparalleled potency. Astaxanthin excels in defending the skin from external damage, including harmful UV radiation, while preserving the skin barrier's integrity. Astaxanthin's antioxidant capacity is remarkably superior, being up to 6000 times stronger than vitamin C, 550 times more potent than vitamin E, and 40 times stronger than beta-carotene in neutralizing free radicals and protecting against oxidative stress.

    Further enhancing the formula, spermidine supports cellular renewal and autophagy, vital for maintaining healthy skin barrier (29, 30). CeraLOK® ceramides are integral for limiting moisture loss and enhancing skin's resilience and texture (31). Niacinamide contributes to this protective barrier by regulating sebum production and enhancing the skin's defense mechanisms (8).

    Additionally, vitamins C and E exhibit remarkable synergy, collectively amplifying their antioxidant effects to bolster the skin's defense against oxidative stress thereby further enhancing the resilience of the skin barrier (32).

  • Sunblock, in a Supplement

    Defend Skin Against Sun and UV Rays

    Cellular Skin Renewal harnesses the synergistic power of vitamins C and E alongside the exceptional benefits of astaxanthin to form a defense against UV rays and sun damage. This unique blend contributes to an advanced internal sunscreen: vitamins C and E work in concert to enhance the skin's protection against UV radiation, reducing sunburn reaction and mitigating the long-term effects of sun exposure (7, 24, 33-35). Astaxanthin, a potent antioxidant, further elevates this protection. When consumed, it accumulates in the skin, acting as an additional shield that extends the time to sunburn and maintains skin health under UV stress (36, 37). This combination of ingredients in Cellular Skin Renewal not only defends against the immediate threats of sun damage but also contributes to the long-term preservation of skin's integrity and youthfulness, providing comprehensive care from the inside out.

  • Feeds Your Fibroblasts

    The Architects of Skin Youth

    Fibroblasts, the workhorse cells nested in the skin's dermis layer, are the architects of collagen and elastin - the building blocks giving your skin its structural integrity and elasticity (38, 39). Proper nourishment of these cells are essential to keep your skin vibrant and youthful for longer.

    Niacinamide sits at the forefront of our Cellular Skin Renewal, serving as a catalyst to stimulate the emergence of new fibroblasts and fueling collagen secretion (40). Alongside, vitamin C steps in, a fundamental element for collagen synthesis. Without an ample supply of vitamin C, fibroblasts could fall short in producing the collagen required to uphold the skin, blood vessels, and other tissues (7). Hyaluronic acid bolsters skin health and the extracellular matrix where fibroblasts thrive (41), while, bioavailable collagen peptides such as VERISOL® awaken fibroblast proliferation and motility, driving the production of more collagen (42).

  • Restore Beneficial Bacteria

    For a Healthier Skin Microbiome

    Cellular Skin Renewal adopts a revolutionary internal approach to foster a healthy skin microbiome, moving beyond the limitations of traditional topical products. The skin microbiome, a complex ecosystem of microorganisms, plays a pivotal role in maintaining skin health. It serves as a frontline defense against pathogens, balances the skin's pH, bolsters natural defenses, and is crucial for retaining moisture. However, the delicate microbiome can be easily harmed by topical skincare products. Such disruptions can lead to reduced skin longevity, and a plethora of skin issues, including acne, eczema, and rosacea (43).

    To counteract these challenges, Cellular Skin Renewal focuses on enhancing the skin's microbiome from within. Central to this strategy is the incorporation of CeraLOK® ceramides. Renowned for their ability to strengthen the skin barrier, ceramides create a balanced environment that nurture beneficial microbes while keeping harmful ones at bay (44).

    Complementing CeraLOK® ceramides, niacinamide plays a crucial role in this formula. Known for its potent antimicrobial properties, niacinamide effectively regulates sebum production. This regulation is key to fostering a healthy skin environment, promoting the growth of beneficial microbes and suppressing the proliferation of detrimental bacteria (45).

  • Harmonize Youthful Skin Tone

    Help Diminish Hyperpigmentation

    The aging process impacts melanocytes - skin cells responsible for melanin production - causing a decrease in melanin, often leading to a lightening or loss of skin vibrancy (46). Conversely, excessive sun exposure or unprotected contact with ultraviolet (UV) rays can cause hyperpigmentation, producing sunspots, age spots, and uneven pigmentation.

    Cellular Skin Renewal is fortified with vitamin C, niacinamide, and CeraLOK® ceramides to combat hyperpigmentation and harmonize skin tone. Vitamin C hinders melanin production, brightening skin and reducing dark spots for a more uniform complexion (7). Niacinamide interrupts pigment transfer within skin cells, resulting in a balanced skin tone and diminished appearance of dark spots (47). CeraLOK® ceramides further improve skin texture and boost the skin's barrier function, supporting the skin's healing process and contributing to a more uniform complexion (31).

  • Defy Sugar-Induced Wrinkles

    Keep Glycation At Bay

    Cellular Skin Renewal addresses the critical issue of glycation, a process that occurs when excess sugar molecules in the bloodstream bind to proteins, lipids, or nucleic acids, forming harmful compounds known as 'advanced glycation end products' (AGEs). AGEs target collagen and elastin, the vital proteins responsible for maintaining skin's structure and elasticity. The result is a breakdown of these proteins, leading to stiffer, less supple skin, prone to wrinkles and sagging (48). AGEs are also linked to chronic inflammation, reactive oxygen species, cellular senescence, and DNA damage, hastening both skin and systemic aging processes (49).

    Combatting glycation is essential for maintaining youthful skin. Cellular Skin Renewal leverages the power of antioxidants like vitamins C and E to neutralize ROS and reduce glycation effects. Niacinamide plays a vital role in inhibiting the formation of AGEs and preventing the associated collagen degradation, thereby aiding in preserving a youthful skin appearance (50). Additionally, N-Acetyl-D-glucosamine is included for its ability to disrupt glycation, preventing sugar molecules from binding to proteins. This action is instrumental in maintaining skin elasticity and reducing the formation of wrinkles (48). This blend of ingredients underlines the importance of smart nutritional strategies in counteracting the age-accelerating impact of sugar on the skin.

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Look inside

  • Collagen Peptides (VERISOL®)

    Collagen, a vital protein responsible for skin structure and elasticity, diminishes with age, resulting in wrinkles and sagging. But most collagen powders available on the market get broken down as normal amino acids (i.e., proteins), without activating collagen production. We’ve harnessed the power of VERISOL®, a unique patented collagen peptide, and one of the few shown to be effective by multiple human trials to actually target and stimulate collagen production in skin, hair, and nails. These components act as the foundational elements of collagen, stimulating its production, enhancing skin by reducing wrinkles, and improving hydration, elasticity, and firmness (2, 4, 5). 2500 mg is the daily recommended dose of VERISOL® for collagen activation.
  • Hyaluronic acid

    Our bodies produce less Hyaluronic acid (HA) as we age, leading to dryness and wrinkles. Known as nature's hydration miracle, it helps retain moisture in skin, keeping it plump. Supplementing HA can improve skin hydration and reduce fine lines and wrinkles, whereas applying it topically does not work: HA molecules are too large to pass through the outer skin layer. HA stimulates collagen synthesis, improving skin firmness and elasticity, promotes healing of skin wounds, and has antioxidant properties that can protect skin from sun damage and premature aging. 150 mg is recommended daily dose for optimal skin health (10, 65). To obtain 150 mg of HA from bone broth, you would need to consume approximately 15-50 cups (3.6-12 liters) of bone broth.
  • Ceramides (CeraLOK®)

    Natural component of the lipidic barrier of the skin that helps maintain its function, preventing moisture loss and keeping the skin hydrated, especially the epidermis. Our skin produces less ceramides as we age, leading to dryness and wrinkles. Ceramides can help improve skin hydration and reduce visible fine lines and wrinkles. CeraLOK®, produced in Japan, has been proven through substantial human studies. CeraLOK® supports enhanced moisturization, hydration, reduced skin roughness, fewer wrinkles, and a brightening effect. Its exceptional absorption and bioavailability are due to its combination with poly-cyclodextrin. CeraLOK® is the only ceramide product incorporating β-sitosterol-3-O-glucoside, contributing significantly to its potency (3, 31, 57). 40 mg of CeraLOK® is the optimal dosage for skin health.
  • N-acetyl-D-glucosamine - NAG

    A hero in the multi-varied process of skin aging, N-acetyl-D-glucosamine or NAG is a natural compound that can help brighten and even out skin tone. It is a precursor of hyaluronic acid biosynthesis as well as it can also promote collagen production. It was shown to inhibit the glycation process, which is one of the leading causes of dermis matrix degradation, and due to that, it can reduce fine lines and wrinkles. A daily dose of 500 mg of NAG is recommended for maximum benefits (58, 59), but as a compound not commonly found in foods, supplementation is the easiest source. A daily dose of 500 mg of NAG is recommended for maximum skin benefits.
  • Spermidine

    Spermidine, a naturally occurring polyamine, has garnered attention for its remarkable impact on skin longevity. Its role in enhancing autophagy, the cellular process of self-cleaning, is crucial for maintaining the health and vitality of skin cells. By promoting the removal of damaged cellular components, spermidine helps slow down the skin's ageing process. This effect is further bolstered by its ability to stimulate collagen production, a key element in preserving skin elasticity and firmness. Additionally, its antioxidant properties provide a shield against oxidative stress, a major contributor to skin aging (9, 22).
  • Niacinamide

    A form of vitamin B3 that can improve skin texture and tone, reduce inflammation, and enhance the skin's barrier function and reduce fine lines and wrinkles. It is a precursor to a longevity molecule NAD+, stimulates collagen and ceramides production (acting on both dermis and epidermis), reduces hyperpigmentation, and increases skin elasticity (8, 61-64).
  • Astaxanthin (AstaZine®)

    Astaxanthin is a natural pigment and a powerful antioxidant in the carotenoid family (found in red marine animals like salmon, krill, and even flamingos). AstaZine® is a certified organic form derived from Haematococcus pluvialis microalgae powder. Astaxanthin has been shown to have photoprotective properties, meaning it can help protect the skin from the damaging effects of UV radiation. It may help reduce sunburn, inflammation, and DNA damage caused by excessive sun exposure. It also helps moisture retention and improves skin tone (29, 36, 37). AstaZine® boasts a wide range of clinically validated health benefits, with 239 approved health claims by the US FDA. 3-6 mg of Astaxanthin is the daily dose recommended for healthy skin and longevity.
  • Vitamin C (Ascorbic Acid)

    Vitamin C, or ascorbic acid, is a water-soluble vitamin, and among the most well studied ingredients for skin health. It is an essential nutrient, meaning the human body cannot synthesize it, and must be obtained through diet or supplements. Besides its antioxidant function that can help protect the skin against oxidative stress, it triggers collagen production and skin cell division. Uniquely, it targets both intrinsic and extrinsic aging at the dermis level (35). Research has indicated that it can diminish fine lines, wrinkles, and age spots, enhancing skin texture and tone (7, 51).
  • Vitamin E

    One of the best and well studied antioxidants for skin, with proven synergy with both vitamin C and carotenoids that can protect the skin against damage from free radicals (34). It can improve skin hydration and reduce stress/sun-induced inflammation. Vitamin E also supports immune function, gene expression, and the metabolism of vitamin K. It is involved in maintaining healthy skin, as it can help protect against UV damage and promote skin healing. To get the same amount of vitamin E from your diet, you would need to eat 10 avocados or 15 red bell peppers (52, 53). 30 mg of Vitamin E is the daily dose recommended for healthy skin.

How to use

Mix one scoop with one cup (8fl oz) water. This can be taken either with or without meals. Take Cellular Skin Renewal daily. For enhanced synergistic effects, combine with Longevity Foundation AM/PM.

+ behavioral protocol

Protect your skin from the sun by applying mineral-based sunscreen. Ensure a balanced diet, sufficient sleep, and effective stress management. Stay hydrated by drinking ample water - hydration is an internal process! Avoid smoking or vaping, as these habits can lead to premature skin aging.


Not recommended for use by children, or by pregnant or nursing women. Before using, it is advised to consult with a healthcare provider, especially if you are currently taking medication or have any chronic medical conditions. This product is not suitable for individuals who are allergic or hypersensitive to any component of the formula.

Skin is one of the most important and complex organs, essential for human longevity. With the frontline of longevity science, we are finally able to address its various mechanisms of deterioration, and create a portfolio approach to truly intervene and even reverse aspects of skin aging.

Francois Xavier Pellay, PhD. Longevity molecule hunter, and world renowned skin longevity expert.

Scientific studiеs

  • Oral versus topical Vitamin C for skin health

    The study highlights the significant impact of Vitamin C on skin health, underscoring its essential role in the synthesis of collagen, a vital component for maintaining skin structure and elasticity. Vitamin C, a powerful antioxidant, also aids in protecting the skin from oxidative stress caused by UV radiation and environmental pollutants, which can lead to premature aging. Importantly, the study emphasizes the superiority of oral supplementation of Vitamin C over topical application. This is primarily because oral intake ensures a more consistent distribution of the nutrient throughout the body, including the skin. In contrast, the effectiveness of topical application is limited due to the challenges in penetrating the skin barrier and achieving adequate concentrations in the dermis. The study concludes that oral supplementation of Vitamin C is a more efficient method for enhancing skin health, promoting better collagen synthesis, and offering comprehensive protection against oxidative damage (7).

  • Ingestion of hydrolyzed collagen for 90 days is effective in reducing skin aging.

    Hydrolyzed collagen supplementation has shown positive effects on human skin aging. A systematic review and meta-analysis of 19 clinical trials revealed that oral intake of hydrolyzed collagen for 90 days resulted in reduced skin wrinkles and improved skin hydration, elasticity, and firmness. The study involved 1,125 participants aged 20 to 70 years, predominantly women. Overall, the findings support the effectiveness of hydrolyzed collagen in combating skin aging (4).

  • Ceramides supplementation improves skin aging by supporting the skin's natural barrier function.

    Ceramides are vital to the skin's lipid barrier, maintaining hydration and protecting against external stressors. Replenishing ceramide levels through supplementation helps strengthen the skin barrier, reducing transepidermal water loss and improving skin moisture levels. This can lead to improved skin elasticity, decreased roughness, and reduce visible signs of aging (68).

  • Cosmeceuticals containing vitamins C, E, and niacinamide are increasingly important in skin care.

    Cosmeceuticals refer to products containing active substances that fall outside the categorization of cosmetics or drugs. Among these, those with vitamins C, E, and B3 have demonstrated potential benefits for mitigating skin aging. Vitamin C is known for its antioxidant properties and ability to stimulate collagen production, reducing wrinkle appearance and enhancing skin elasticity. Vitamin E also functions as an antioxidant, safeguarding the skin against damage caused by free radicals. Vitamin B3, also known as niacinamide, has positively enhanced the skin's protective barrier, minimized hyperpigmentation, and refined skin texture. (33, 67).

  • Long-term prophylactic astaxanthin supplementation may inhibit age-related skin deterioration and maintain skin conditions associated with environmentally induced damage

    Astaxanthin, a potent antioxidant, and anti-inflammatory carotenoid, was evaluated for its anti-inflammatory effects on skin deterioration. In vitro, experiments demonstrated that astaxanthin reduced inflammatory cytokine secretion in keratinocytes and matrix metalloproteinase-1 secretion in UVB-irradiated fibroblasts. A 16-week clinical study involving 65 healthy female participants found that oral administration of astaxanthin (6 mg or 12 mg) prevented the worsening of wrinkle parameters and skin moisture content compared to the placebo group. Additionally, interleukin-1α levels in the stratum corneum increased in the placebo and low-dose groups but not in the high-dose group (36).

  • N-acetyl-D-glucosamine is a hyaluronic acid precursor accelerating wound healing, improving skin hydration, and decreasing wrinkles.

    N-Acetyl-D-glucosamine (NAG) is a naturally occurring form of glucosamine that is structurally analogous to components found in the human body. Its bioavailability, or the ease with which the body can absorb and utilize it, is reported to be three times greater than other forms of glucosamine. Glucosamine and its derivative, N-acet-D-glucosamine, have important bodily functions, including the synthesis of hyaluronic acid and proteoglycans (69). They have been shown to provide various benefits for the skin, such as promoting wound healing, improving skin hydration, reducing wrinkles, and inhibiting melanin production for hyperpigmentation treatment (59).

  • Recovery of Human Dermal Structure and Barrier Function Induced by Spermidine through the Skin Microbiome.

    This study reveals the significant role of Streptococcus species, particularly S. pneumoniae, S. infantis, and S. thermophilus, in improving skin structure and barrier function, contributing to anti-aging. The numbers of these bacteria is higher in younger individuals or those with more elastic skin, and their secretions, especially spermidine, enhance collagen and lipid synthesis in aged cells. These findings highlight the potential of leveraging the skin microbiome, particularly Streptococcus-secreted compounds like spermidine, in developing anti-aging skincare treatments (9).

  • The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

    NAD (Nicotinamide Adenine Dinucleotide) plays a crucial role in maintaining skin health and combating aging. Daily environmental factors, especially solar radiation, induce oxidative stress, disrupting skin's normal functioning and accelerating aging. This stress depletes NAD+ and ATP levels, affecting cellular energy and leading to chronic damage, particularly in mitochondria. NAD+ and its precursor, nicotinamide, are key to skin homeostasis. They are linked to dietary requirements and are beneficial in treating inflammatory conditions, preventing photoaging, and reducing cancer risk. Aged skin shows lower NAD+ levels, and nicotinamide supplementation can help restore these, mitigating energy dysfunction. It protects dermal fibroblasts from oxidative damage, enhances mitochondrial efficiency, and supports selective mitophagy through sirtuin activation. NAD+ levels are dynamic, influencing cellular metabolism, mitochondrial function, and circadian rhythms. Understanding NAD+'s role in skin biology is vital for developing interventions to maintain skin health and cellular bioenergetics, especially against UV-induced stress (14).

  • Induction of autophagy by spermidine promotes longevity

    Spermidine, a natural polyamine found to decline with age, has emerged as a significant factor in promoting longevity. This groundbreaking study reveals that spermidine supplementation remarkably extends the lifespan of yeast, flies, worms, and even human immune cells. Moreover, it offers potent protection against oxidative stress in aging mice. The key to spermidine's efficacy lies in its ability to induce epigenetic changes, particularly the deacetylation of histone H3. This process, driven by the inhibition of histone acetyltransferases (HAT), leads to reduced oxidative stress and necrosis in aging yeast. On the flip side, reduced levels of endogenous polyamines correlate with increased acetylation, reactive oxygen species production, early necrotic death, and a shortened lifespan. Spermidine's impact extends to upregulating autophagy-related transcripts, thereby triggering autophagy in various organisms and human cells. This enhanced autophagy is essential for spermidine's role in suppressing necrosis and boosting longevity, underscoring its potential as a powerful anti-aging intervention (22).

  • Oral intake of VERISOL® reduces skin wrinkles and increases dermal matrix synthesis

    VERISOL®, a specific bioactive collagen peptide (BCP), has been clinically proven to be effective in reducing skin aging, particularly eye wrinkle formation. In a rigorous double-blind, placebo-controlled study involving 114 women aged 45-65, participants receiving 2.5 g of VERISOL® daily for 8 weeks showed a significant reduction in eye wrinkle volume. Notably, this effect persisted even four weeks after ceasing intake, highlighting its lasting benefits. Beyond just wrinkle reduction, VERISOL® remarkably enhanced the skin's internal structure. After 8 weeks of consistent use, there was a substantial increase in the skin's procollagen type I content by 65% and elastin by 18%, compared to those on a placebo. These components are crucial for maintaining skin elasticity and firmness. Although the increase in fibrillin was a modest 6%, VERISOL®'s overall impact on enhancing dermal matrix synthesis is evident. These findings underscore VERISOL®'s efficacy in not only visibly reducing wrinkles but also improving the skin's overall health and youthful appearance from within (25).

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Science-Backed Ingredients backed by hundreds of studies, reviewed by leading longevity experts
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  • How should I take Cellular Skin Renewal?

    Mix one scoop with one cup (8fl oz) water. This can be taken either with or without meals. Take Cellular Skin Renwal daily. For enhanced synergistic effects, combine with Longevity Foundation AM/PM.

  • Are there any known side effects?

    The ingredients in Cellular Skin Renewal are typically well-tolerated, but individual responses may differ. As with any dietary supplement, seeking advice from your healthcare professional before initiating a new supplement regimen is advisable. This is particularly important if you have underlying medical conditions or are taking medications, and consulting with a healthcare professional ensures personalized guidance and compatibility with your circumstances.

  • How long does it take to see results with Cellular Skin Renewal?

    Results may vary depending on individual factors such as overall health, lifestyle, and genetics. Consistent use of the Cellular Skin Renewal, along with a healthy diet and skincare routine, can contribute to visible improvements in the skin's appearance over time. However, with consistent use, many have reported positive results in as little as 4 weeks, and as long as 3 months.

  • Does Cellular Skin Renewal replace a healthy skincare routine?

    Cellular Skin Renewal is designed to complement a healthy skincare routine, not replace it. While the supplement can provide essential nutrients to support skin health, it is important to maintain a comprehensive skincare regimen that includes healthy diet, adequate hydration, sun protection, avoiding smoking and high sugar foods, and other skincare practices suitable for your skin type and concerns.

  • Can Cellular Skin Renewal cure skin conditions or diseases?

    Cellular Skin Renewal is a dietary supplement not intended to diagnose, treat, cure, or prevent skin conditions or diseases. If you have specific skin concerns or medical conditions, it is important to consult with a dermatologist or healthcare professional for proper diagnosis and treatment.

  • Can I take Cellular Skin Renewal if I'm already taking other skincare supplements?

    It is generally safe to take Cellular Skin Renewal alongside other skincare supplements. However, consulting with a healthcare professional or pharmacist is recommended to ensure no potential interactions between the different supplements you are taking.

  • What else can I do to enhance the effectiveness of Cellular Skin Renewal.

    Cellular Skin Renewal is designed to be stackable and have powerful synergistic effects with Longevity Foundation AM/PM. We also recommend protecting your skin from the sun by applying mineral-based sunscreen. Ensure a balanced diet, sufficient sleep, and effective stress management. Stay hydrated by drinking ample water. Avoid smoking or vaping, as these habits can lead to premature skin aging.


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    1. Tzaphlidou M. The role of collagen and elastin in aged skin: an image processing approach. Micron. 2004;35(3):173-7.

  2. Reference link

    2. Bolke L, Schlippe G, Gerß J, Voss W. A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients. 2019;11(10).

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    3. Sun Q, Wu J, Qian G, Cheng H. Effectiveness of Dietary Supplement for Skin Moisturizing in Healthy Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Nutr. 2022;9:895192.

  4. Reference link

    4. de Miranda RB, Weimer P, Rossi RC. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol. 2021;60(12):1449-61.

  5. Reference link

    5. Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin pharmacology and physiology. 2014;27(1):47-55.

  6. Reference link

    6. Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015;18(12):1340-8.

  7. Reference link

    7. Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017;9(8).

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