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The Master Formula
Over the past decade, science has begun mapping the root causes of biological aging. Known as 'The 12 Hallmarks of Aging', this offers us a framework to address each driver of aging, one by one. With this newfound understanding, specific 'longevity molecules' have drawn attention for their unique ability to target each hallmark. These are not just 'health' supplements - longevity molecules are selected and studied for their specific ability to intervene within the complex mechanisms of aging.
Sleep optimization
Sleep is nature’s longevity miracle: some of the most important biological rejuvenation mechanisms – like cellular repair, muscle growth, protein synthesis - happen during sleep. Sleep is the common denominator of brain health, hormone health, mental health, heart health, metabolic health, and immune health. In fact, it’s been found that the health risks associated with poor sleep are comparable to smoking. But not all sleep is created equal, and while it may be tempting to focus on sleep length, it’s sleep quality that can make the biggest difference. Sadly, as you age, your circadian rhythm dysregulates, life gets in the way, and your body has an increasingly difficult time getting quality sleep and its myriad of benefits.
Skin Health
Skin is your largest organ - it's literally holding you together. But keeping skin young and healthy is not just for show - it's a real health concern. Skin plays a critical role in protection, sensation, and temperature regulation, and is the body’s largest buildup of senescent cells. These ‘zombie cells’ leave the skin, cause damage, and accelerates aging throughout the rest of the body. Sadly, most skincare is cosmetic, failing to address the deeper mechanisms of skin aging. Longevity Science heralds a new era for this organ, as it maps out the unique process of dermal aging and its complex relationship with the body's health.
Glucose Restriction
Maintaining healthy blood sugar levels is pivotal for longevity, given the unprecedented level of sugar and carbohydrates in modern diets. Healthy blood sugar combats insulin resistance, chronic inflammation, and supports hormonal health, crucial for systemic well-being. It also maintains mitochondrial function and minimizes harmful by-products that damage cells and causes wrinkles. Importantly, stable glucose levels influence transcriptional pathways and activate longevity genes, such as hTERT and FOXO proteins, which protect DNA integrity and enhance metabolic flexibility.
FASTING & CALORIC RESTRICTION
Intermittent fasting and caloric restriction have garnered significant interest for their potential to enhance healthy longevity. These practices not only stimulate autophagy, cellular renewal, reduced oxidative stress, and promote mitochondrial efficiency, but they also improve metabolic health, including better glucose regulation and insulin sensitivity. In fact, a landmark study by Columbia University (the 'CALERIE trial’) showed that caloric restriction can slow the pace of biological aging in humans as measured by a DNA methylation test.
Testing
COMING FALL 2024. Biological age testing is central to longevity science. By distinguishing between chronological age — the number of years since birth — and biological age, reflecting the true condition of a body, we're offered a new way of measuring health. But a biological age is just the beginning - biomarker testing, comprehensive health diagnostics, and simple at-home measurement tools are your trusted partners in achieving longevity goals.