Glucose
Glucose Blocker
Glucose Blocker
Glucose Blocker
Glucose Blocker
Glucose

Glucose Blocker

Our Glucose Blocker, taken with meals, helps combat one of the leading lifestyle contributors to premature aging - volatile blood glucose levels. Modern diets are saturated with glucose, present in everything from processed carbohydrates to sugary desserts. Constant high blood glucose levels can result in insulin resistance and stimulate glycation, leading to inflammation, oxidative stress, and tissue harm - significant factors in skin aging. Glucose Blocker regulates post-meal glucose levels, providing steady energy without severe spikes and crashes associated with carb intake. Its natural ingredients decelerate glycation, prevent oxidative stress, and possess anti-inflammatory properties. Our proprietary formula features Berberine, an extraordinary molecule recognized for its ability to activate critical pathways linked to longevity. Plus, Glucose Blocker helps curtail the absorption of sugar-related calories, aiding in weight management and sugar reliance. Enjoy your carby meals with less guilt!
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Glucose Blocker
Ingredients
Chromium (as chromium chloride)
200 mcg
White mulberry leaf extract
200 mg
Berberine HCL
200 mg
Gymnema sylvestre leaf extract
180 mg
White kidney bean extract
400 mg

Cheat your cheat meals

Master your sugar, unlock your healthy longevity

Why it’s different

  • Defy Blood Sugar Spikes

    From Carbs and Sugars

    Carbohydrates, particularly refined ones, swiftly transform into glucose in the body. This rapid conversion leads to sudden spikes in blood sugar, increasing your body’s demand for insulin. Over time, this demand can culminate in insulin resistance - a health concern alarmingly prevalent in 38% of US adults. Persistent high insulin levels can be a gateway to chronic illnesses such as diabetes and heart disease, shortening your lifespan.

    Our Glucose Blocker, packed with chromium, works to heighten insulin sensitivity and ensure efficient glucose absorption. This prevents post-meal blood sugar surges. Potent ingredients like berberine and Gymnema sylvestre act as a safety net, effectively lowering blood sugar levels by enhancing insulin sensitivity and curbing liver glucose production (1). Furthermore, we've added components like white mulberry leaf extract and white kidney bean extract. These star ingredients block the breakdown of carbohydrates, effectively minimizing the overall glucose that makes its way into your bloodstream (2). So, with Glucose Blocker, you're better equipped to shield against blood sugar spikes and manage your carb and sugar intake.

  • Combat Aging and Wrinkles

    Caused by Glycation (Caused by Sugars)

    Glycation is a process where excess blood sugar interacts with proteins, leading to harmful advanced glycation end products (AGEs). These AGEs accelerate aging, causing visible signs like wrinkles and age spots, and intensifying factors like chronic inflammation and nutrient sensing irregularities (3). Glucose Blocker provides a powerful counter to glycation. By controlling glucose spikes and combating inflammation and oxidative stress, it helps keep your skin looking youthful. This is all made possible through its blend of powerful ingredients like berberine and mulberry leaf extract (4).

    Further reinforcing this protection, chromium chloride plays a critical role in carbohydrate metabolism, enhancing insulin action for better glucose management and reducing glycation (5). Gymnema sylvestre, an Ayurvedic staple recognized for its 'sugar-destroying' properties, assists in regulating blood sugar levels, further curbing glycation and its damaging effects (6). Moreover, white kidney bean extract functions as a 'carb blocker', inhibiting an enzyme involved in breaking down carbohydrates. This results in less sugar absorption post meals, contributing to lower glycation levels (7). With Glucose Blocker, you manage your blood sugar levels and take a firm stand against aging and its visible signs.

  • Fend Off Sugar Cravings

    Say Goodbye to the Sweet Tooth

    Craving sugar is more than a desire for something sweet. It's often a plea from your brain for a "reward" rather than your body's need for fuel. Factors such as stress, gut health imbalance, irregular blood sugar levels, and inadequate sleep can trigger these cravings, leading to a search for a quick energy boost found in sugary food (8).

    Glucose Blocker's key ingredient, Gymnema sylvestre-derived gymnemic acid, combats these cravings by delaying blood glucose absorption, which can curb hunger and the desire for sweet foods. Acting like glucose molecules, gymnemic acid dulls your taste buds' ability to detect sugar, toning down your sweet tooth. It also occupies receptors in your intestine, blocking sugar absorption and effectively managing blood sugar levels (1, 9-15).

    Another star ingredient, white mulberry extract, adds to this defence. Consumed with a meal, it misleads enzymes into believing they're digesting carbs. This ruse allows real carbs to bypass digestion, triggering the 'ileal brake'. This process sends a 'fullness' signal to the brain when undigested food reaches the ileum, the final part of the small intestine, helping you feel satisfied and reducing cravings (16, 17). With Glucose Blocker, you're not just curbing your sugar cravings but controlling them for good.

  • Support Your Weight Loss Journey

    Reimagine Calorie Absorption

    Merely eating less may not tip the scale in your favour. The key to successful weight loss also involves ensuring your body absorbs fewer calories. That's where Glucose Blocker steps in with a dual approach for comprehensive weight management.

    Glucose Blocker leverages the strength of mulberry leaf extract and white kidney bean extract, managing calorie absorption to aid your weight loss efforts. Our formula includes white mulberry leaf extract, rich in 1-deoxynojirimycin, slowing down how your body processes and absorbs carbohydrates. Concurrently, phaseolamin from white kidney bean extract inhibits alpha-amylase, reducing your intake of carb-based calories (17-21).

    This potent pair serves your weight management goals by maintaining controlled calorie absorption while still supplying your body with vital nutrients. With Glucose Blocker, your weight loss journey becomes more manageable, and your progress, more noticeable.

  • Cheat Your Cheat Meals

    Perfect for Keto Warriors

    Adhering to a ketogenic diet requires discipline, turning to ketones for energy as the liver breaks down fat due to glucose scarcity. Ketosis can lead to fat burning, appetite control, stable blood sugar levels, and numerous potential health benefits (22, 23). But who doesn't love a good cheat meal occasionally?

    Glucose Blocker ensures your cheat meals don't take you too far from ketosis. It combines the power of white mulberry leaf extract and white kidney bean extract to slow down carbohydrate digestion and limit glucose absorption, thus minimizing glucose spikes and maintaining ketosis even when indulging (21). Mulberry leaf hinders the enzymes that simplify complex carbohydrates into sugars, decreasing the glycemic index of the carbs you eat - essential for staying in ketosis (24).

    Additionally, Gymnema sylvestre helps delay glucose absorption in your intestines, maintaining the steady blood glucose levels critical to preserving ketosis (25). White kidney bean extract acts as a starch 'blocker,' inhibiting the enzyme alpha-amylase responsible for breaking down starches into sugars. This reduction in carbohydrate digestion can help to reduce the blood glucose spike after a carb-laden cheat meal, helping you to maintain ketosis, or not stray too far from it (7). So, go ahead and enjoy your cheat meals with less guilt.

  • Combat Inflammation, Bolster Antioxidant Defense

    For Whole Body Health

    Pervasive inflammation can accelerate aging and lead to chronic diseases like heart disease, cancer, and Alzheimer's (26-28). Glucose Blocker combats inflammation with potent anti-inflammatory compounds and antioxidants. Its chromium content aids in reducing inflammation markers like C-reactive protein (CRP) and interleukin-6 (IL-6) (29).

    The high flavonoid content in white mulberry leaf extract and Gymnema sylvestre helps counter harmful free radicals, mitigating inflammation. Furthermore, they inhibit the production of pro-inflammatory cytokines, reducing inflammation (30, 31).

    Berberine, a powerful plant-derived compound, is celebrated for its potent anti-inflammatory and antioxidant properties. It moderates multiple pathways, including suppressing nuclear factor-kappa B (NF-κB) and activating AMP-activated protein kinase (AMPK), diminishing inflammation and oxidative stress (32). Consequently, this may reduce the risk of chronic illnesses linked to oxidative stress, including cancer, cardiovascular disease, and cognitive decline (2, 20, 28).

  • Dodge Energy Crashes

    Triggered by Glucose Spikes

    Sharp spikes in blood sugar levels can lead to rapid drops - known as 'energy crashes' or 'insulin crashes' - characterized by feelings of fatigue, weakness, and an inability to focus (33). Glucose Blocker helps to stabilize blood sugar levels and prevent these debilitating energy dips. This allows you to maintain a consistent level of energy throughout your day, staying active and focused without the fear of sudden fatigue.

    White mulberry leaf extract and white kidney bean extract further limit the absorption of carbohydrates, thus preventing sudden increases in blood glucose (2). Berberine improves insulin sensitivity and promoting glucose metabolism, leading to more stable blood sugar levels. It does so by activating an enzyme called AMPK, an energy sensor that regulates glucose and lipid metabolism (34).

  • Boost AMPK and FOXO3A Longevity Proteins

    For Healthy Longevity

    The proteins AMPK and FOXO3A are critical in regulating cell metabolism and supporting longevity. Glucose Blocker's natural ingredients are designed to activate and enhance these proteins. Chromium chloride and berberine stimulate AMPK, promoting glucose uptake and insulin sensitivity (26, 35, 36). Gymnema sylvestre activates AMPK and boosts FOXO3A activity, leading to increased gene expression associated with cellular repair and antioxidant defense, promoting cellular health and longevity (37). Furthermore, the white mulberry leaf extract can activate FOXO3A, contributing to cell repair and defense against oxidative stress (38). Thus, Glucose Blocker enhances your longevity mechanisms.

  • Unveiling Berberine

    One of Longevity's Best Kept Secrets

    Berberine, a compound found in various plants like barberry and Oregon grape, is a powerful but often overlooked longevity enhancer. Used in traditional Chinese medicine, it offers a plethora of benefits from blood sugar regulation to countering cellular aging. Studies reveal berberine's potential to amplify AMPK activation, boost autophagy (the process where cells eliminate unnecessary or dysfunctional components), and curb apoptosis (cell death) induced by high glucose levels. These effects parallel those of increased physical activity and decreased caloric intake. Berberine's effectiveness is so compelling that it's often recommended to diabetic and pre-diabetic individuals alone or alongside conventional diabetes medications (28, 34). Recent studies indicate that berberine can match the effectiveness of several diabetes drugs - including metformin, a well-studied longevity-enhancing drug. Its so powerful, that daily 1 gram of berberine intake has been shown to reduce blood sugar levels by 20%, bringing them from diabetic to non-diabetic ranges (39).

How can blood sugar spikes affect the 12 hallmarks of aging?

Learn more

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Look inside

  • Chromium Chloride

    Chromium is a trace mineral that plays a vital role in glucose metabolism, and it enhances insulin sensitivity and glucose uptake in cells, thus reducing blood sugar levels. Studies have shown that chromium supplementation can improve glucose control in people with diabetes, reduce the risk of developing diabetes, and improve insulin resistance in people with metabolic syndrome. In addition, chromium supplementation has been shown to have anti-aging effects, such as reducing oxidative stress and inflammation and improving lipid metabolism. It can be found in broccoli, but to get 20mg of chromium from broccoli alone, you would need to consume 100 cups of cooked broccoli (20, 21, 29, 36, 40-43).
    formula

  • White mulberry leaf extract

    White mulberry leaf extract (Morus alba) has been traditionally used in Chinese medicine and Japanese tea for centuries. It contains 1-deoxynojirimycin, which limits carbohydrate breakdown into glucose, reducing glucose absorption and lowering post-meal blood sugar levels. Additionally, it possesses antioxidant properties and reduces inflammation. Research indicates its efficacy in improving glucose control and insulin sensitivity, and in reducing diabetes risk (2, 4, 20, 38, 44-46). To get the same amount of 1-deoxynojirimycin as in Glucose Blocker you would need to eat 1kg (2.20 lbs) of ripe figs.
    formula

  • Berberine

    Berberine, found in plants like Huanglian, Barberry, Oregon grape, and Tree Turmeric, is a traditional Chinese remedy for ailments including blood sugar. It's a powerful activator of the pro-longevity AMP-activated protein kinase (AMPK) signaling pathway, crucial for glucose metabolism (26-28, 35). This results in enhanced glucose uptake, reduced liver glucose production, and increased insulin sensitivity. Berberine's anti-inflammatory and antioxidant properties also help lower the risk of age-related diseases. Studies indicate its effectiveness in improving glucose control, reducing insulin resistance, and enhancing lipid metabolism. Berberine notably extends lifespan and health in model organisms and mice, aiding cell rejuvenation and growth, even under natural aging and chemotherapy-induced senescence.
    formula

  • Gymnema sylvestre extract

    Gymnema sylvestre, known as the "sugar destroyer," is a shrub from tropical forests of India, Africa, and Australia, used in Ayurvedic medicine to suppress sugar taste. Its gymnemic acids bind to the tongue's sugar receptors, reducing sugar's taste. By helping maintain healthy blood glucose levels, Gymnema sylvestre could contribute to a reduction in AGE formation, supporting healthier aging. Gymnema sylvestre is also known for its potential weight loss benefits, studied for its potential to suppress appetite and promote feelings of fullness, which could support healthier weight management (1, 49).
    formula

  • White kidney bean extract

    White kidney bean extract is derived from the white kidney bean (Phaseolus vulgaris) plant, also known as Phaseolus vulgaris extract, Phase 2, or Phaseolamin. The extract is made from plant beans and is rich in a substance called phaseolamin, an alpha-amylase inhibitor. This substance is believed to help prevent the breakdown and absorption of carbohydrates by inhibiting the action of the enzyme alpha-amylase, responsible for breaking down carbohydrates into simple sugars that the body can absorb. As a result, white kidney bean extract is often considered as a weight loss supplement and as a way to help regulate blood sugar levels (2, 18-21).
    formula

How to use

Healthy adults should take two (2) capsules with meals, especially meals high in carbohydrates or sugar. For enhanced effectiveness, take 15 minutes before eating. It is advisable to accompany this regimen with a balanced diet consisting of whole, unprocessed foods, and to regularly monitor glucose levels for pattern identification and necessary adjustments. For enhanced synergistic effects, combine with Longevity Foundation AM/PM.

+ behavioral protocol

Portion Control: Monitor portion sizes; overeating can cause sugar levels to spike. Choose Low Glycemic Index Foods: such as non-starchy vegetables and whole grains, which are absorbed slowly. Meal Phasing: Always start your meals with something fiber-rich, like vegetables or salad. This helps to slow glucose absorption. Take a Walk: Engaging in light movement after meals can aid in mopping up excess blood sugar.

+ WARNING

Not recommended for children, pregnant, or nursing women. Consult a healthcare provider before use, especially if you are on medication or have conditions like liver or kidney problems, heart disease, high blood pressure, cholesterol issues, or digestive disorders. Not advised for those on oral hypoglycemic agents, insulin, or other medicines affecting blood glucose levels. Not for individuals allergic or hypersensitive to any formula component.

Elevated blood sugar levels are linked to the development of many age-related diseases, including heart disease, dementia, and cancer.

Dr. David Sinclair, PhD. Professor in the Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School

Scientific studiеs

  • Advanced glycation end products (AGEs) and longevity

    AGEs are associated with an increased risk of cardiovascular disease and mortality in older adults. The study followed over 1,000 participants for a median of 9 years and found that those with higher levels of AGEs had a significantly higher risk of cardiovascular events and death. The authors suggest that reducing AGE intake through dietary modifications or supplements may help improve longevity and reduce the risk of chronic diseases (50).

  • Effects of chromium supplementation on glucose control

    In this study, researchers investigated the effects of chromium and polyphenols from cinnamon on insulin sensitivity in human and animal subjects. The results showed that supplementation with chromium and cinnamon improved insulin sensitivity and glucose metabolism, suggesting a potential role in managing glucose levels. The study provides evidence for using chromium to control glucose levels and insulin sensitivity (51).

  • Effects of mulberry leaf extract on the rise in blood glucose after a meal

    The study found that participants who consumed a mulberry leaf extract beverage had a significantly lower postprandial (post meal) glucose response than the control group. The researchers concluded that mulberry leaf extract might help manage postprandial glucose levels and prevent insulin resistance (52).

  • Benefits of berberine in longevity and managing diabetes

    Berberine may have a therapeutic effect on glucose metabolism and insulin resistance. The article suggests that berberine may have a protective effect on various organs in the body, which could lead to increased longevity (34).

  • Gymnema sylvestre administration decreased body weight, BMI, and very low-density lipoprotein levels in subjects with metabolic syndrome.

    This clinical study investigated the impact of Gymnema sylvestre, a medicinal plant, on metabolic syndrome, insulin secretion, and insulin sensitivity. The randomized, double-blind, placebo-controlled trial included 24 patients aged 30-60 years, diagnosed with metabolic syndrome. These patients were given G. sylvestre or a placebo twice daily before meals for 12 weeks. Post-administration, the study found significant reductions in patients' body weight, body mass index (BMI), and very low-density lipoprotein (VLDL) levels. However, there were no observed changes in metabolic syndrome components, insulin secretion, or insulin sensitivity. The results suggest that G. sylvestre can potentially aid in weight management and lipid profile improvement without affecting insulin function (53).

  • Effect of white kidney bean extract, mulberry leaf extract, and niacin-bound chromium complex on glycemic control in obese diabetic mice.

    The results showed that the food mixture with white kidney bean extract, mulberry leaf extract, and niacin-bound chromium complex improved glucose tolerance and insulin sensitivity in the mice, reduced fasting blood glucose and HbA1c levels, and improved glycemic control in obese individuals with diabetes (20).

  • Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates

    Mulberry leaf extract (MLE), containing 1-Deoxynojirimycin, has been highlighted in a study for its potential in managing blood sugar levels. The research, conducted with 15 healthy volunteers, found that MLE significantly reduces postprandial hyperglycemia by inhibiting carbohydrate digestion. The study observed lower glycemic index values for common dietary sugars such as sucrose, maltose, and maltodextrin when combined with MLE, with reductions in glycemic impact up to 53.11%. This indicates that MLE can effectively moderate blood sugar spikes following meals. The findings suggest that MLE could be beneficial in managing blood sugar responses to carbohydrate-rich foods, and it was well-tolerated by participants, underscoring its potential as a natural aid for blood sugar control (24).

  • Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

    This study highlights the effects of berberine in promoting longevity and enhancing cellular health. In the research, berberine's ability to activate AMP-activated kinase (AMPK) is central to its impact. This activation leads to a cascade of beneficial effects, primarily through enhancing the function of Sirt1, a protein vital for cellular survival. Sirt1 supports key processes such as autophagy, DNA repair, and mitochondrial biogenesis, crucial for maintaining cellular integrity and combating age-related damage. The study underscores berberine's potential in fostering healthful longevity by maintaining efficient cellular functions and protecting against cellular stress and aging. The findings position berberine as a noteworthy agent in targeting age-related degenerative changes and promoting overall cellular health, based on its interactions with AMPK and Sirt1 (26).

  • Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

    Berberine has been shown to have significant health benefits, particularly in lowering cholesterol and blood sugar levels. The study reveals that berberine works by increasing cholesterol uptake in the liver and reducing the production of proteins that raise cholesterol levels. Additionally, it aids in lowering blood sugar by enhancing glucose utilization in muscle and fat cells and reducing its absorption in the intestines. In animal studies, berberine effectively reduced cholesterol levels, which is beneficial for heart health. It also showed promise in diabetic animals by lowering blood sugar levels and aiding in weight control. Clinical trials in humans have mirrored these results, with berberine demonstrating a significant reduction in cholesterol and blood sugar levels, and it did so with minimal side effects. These findings are quite promising, suggesting berberine could be a valuable natural alternative for treating certain health issues (34).

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FAQ’s

  • Can I take Glucose Blocker if I am on a Keto diet or other low carb diets?

    Yes, Glucose Blocker can be beneficial if you're on a ketogenic or low carb diet as it helps regulate blood glucose levels and may help reduce the impact of any higher-carb meals on your blood sugar levels.

  • How long does it take to see results with the Glucose Blocker?

    The timing may vary depending on individual health status, diet, and lifestyle factors. Some may see a difference in their blood sugar levels within a few weeks, while for others it might take longer. Regular monitoring of your blood sugar levels and consistent use of the supplement is advised for best results.

  • Can Glucose Blocker help with weight loss?

    While Glucose Blocker is primarily designed to help control blood sugar levels, some ingredients, like Gymnema sylvestre and white kidney bean extract, have been associated with weight management. However, it should be used in conjunction with a balanced diet and regular exercise for optimal results.

  • How long should I take this supplement?

    This supplement can be taken long-term as part of a healthy lifestyle. Taking breaks after several months of continuous use is recommended to track changes and assess need. You may find that your relationship to carbs and sugars has radically changed over time, and you no longer feel you need support. If so, that's great! Pick another longevity goal to tackle :)

References

  1. Reference link

    1. Kumar PM, Venkataranganna MV, Manjunath K, Viswanatha GL, Ashok G. Methanolic leaf extract of Gymnema sylvestre augments glucose uptake and ameliorates insulin resistance by upregulating glucose transporter-4, peroxisome proliferator-activated receptor-gamma, adiponectin, and leptin levels in vitro. J Intercult Ethnopharmacol. 2016;5(2):146-52.

  2. Reference link

    2. Lange E, Kęszycka PK, Pałkowska-Goździk E, Billing-Marczak K. Comparison of Glycemic Response to Carbohydrate Meals without or with a Plant-Based Formula of Kidney Bean Extract, White Mulberry Leaf Extract, and Green Coffee Extract in Individuals with Abdominal Obesity. International Journal of Environmental Research and Public Health. 2022;19(19):12117.

  3. Reference link

    3. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023;186(2):243-78.

  4. Reference link

    4. Khalifa I, Xia D, Dutta K, Peng J, Jia Y, Li C. Mulberry anthocyanins exert anti-AGEs effects by selectively trapping glyoxal and structural-dependently blocking the lysyl residues of β-lactoglobulins. Bioorganic chemistry. 2020;96:103615.

  5. Reference link

    5. Vincent JB. The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent. Sports medicine (Auckland, NZ). 2003;33(3):213-30.

  6. Reference link

    6. Kang MH, Lee MS, Choi MK, Min KS, Shibamoto T. Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats. J Agric Food Chem. 2012;60(10):2517-24.

  7. Reference link

    7. Barrett ML, Udani JK. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): A review of clinical studies on weight loss and glycemic control. Nutrition journal. 2011;10(1):24.

  8. Reference link

    8. Ma Y, Ratnasabapathy R, Gardiner J. Carbohydrate Craving-not everything is sweet. Current opinion in clinical nutrition and metabolic care. 2017;20(4):261.

  9. Reference link

    9. Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol. 1990;30(3):281-94.

  10. Reference link

    10. Al-Romaiyan A, King AJ, Persaud SJ, Jones PM. A novel extract of Gymnema sylvestre improves glucose tolerance in vivo and stimulates insulin secretion and synthesis in vitro. Phytother Res. 2013;27(7):1006-11.

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