Sleep
Advanced Sleep Repair 
Advanced Sleep Repair 
Advanced Sleep Repair 
Advanced Sleep Repair 
Advanced Sleep Repair 
Sleep

Advanced Sleep Repair 

Advanced Sleep Repair transcends traditional sleep aids, offering a complete, precision-targeted protocol focused on amplifying restorative and age-reversing processes. Recognized by experts as the ultimate tool for essential bodily repair, sleep is a cornerstone of performance and aging. But starting in your mid-20’s, your body's circadian rhythm and overnight repair mechanisms gradually decline, leading to diminished sleep quality, accelerated bodily deterioration, and cognitive decline - inflicting more harm on your body than smoking (1). Through a precision blend of L-theanine, GABA, glycine, magnesium, vitamin B6, L-tryptophan, sour cherry extract, taurine and zinc, Advanced Sleep Repair meticulously targets and corrects these deficiencies, enhancing DNA repair and metabolic balance, combats oxidative stress, fostering healthy neurotransmitter levels, and naturally fine-tuning serotonin and melatonin levels crucial for sleep-wake cycles. 
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Advanced Sleep Repair 
Ingredients
Vitamin B6 (as pyridoxal-5-phosphate)
15 mg
Magnesium (as magnesium amino acid chelate complex)
400 mg
Zinc (as zinc bisglycinate chelate)
30 mg
Glycine
2,500 mg
Taurine
1,000 mg
GABA (gamma-aminobutyric acid)
750 mg
FruitSOURCE® tart cherry fruit
500 mg
L-Theanine
400 mg
L-Tryptophan
150 mg

Your sleep, supercharged for longevity

A complete protocol for peak performance, deep rejuvenation, and superhuman healthy longevity

Why it’s different

  • ENGINEERED FOR SMARTER SLEEP

    Quality, not quantity

    Advanced Sleep Repair is far more than a standard sleep aid; it doesn’t sedate you into prolonged, unproductive slumber. Instead, it's a meticulously engineered sleep protocol, focusing on enhancing the restorative and regenerative aspects of sleep for enhanced performance and longevity. This enables you to fully benefit from your body's natural rejuvenation and healing processes, ensuring you wake up refreshed and alert - the true indicators of sleep's success in replenishing both body and mind (2).

    The product uses a multi-modal methodology that targets the 'three drivers of sleep quality':

    • 1. efficiency, encompassing uninterrupted sleep and fluid sleep flow (3);
    • 2. architecture, involving well-structured sleep stages including NREM, REM, light, and deep sleep, crucial for both physical and mental restoration (4);
    • 3. depth, the vital phase of deep sleep characterized by slow brainwave activity essential for physical and mental rejuvenation (5).

  • SUPPORTS NATURAL MELATONIN PRODUCTION

    COMBAT AGE-RELATED CIRCADIAN DYSREGULATION

    Melatonin, the 'sleep hormone,' plays a vital role in synchronizing our internal biological clock or circadian rhythm, initiating the sleep process, and maintaining a healthy sleep-wake cycle – a crucial component for healthy aging (6-8).

    As we age, melatonin production declines, contributing to disrupted sleep. Interestingly, melatonin is also linked to the aging process itself due to its antioxidant properties, reducing oxidative stress, and its anti-inflammatory effects, potentially mitigating chronic inflammation associated with age-related diseases causing experts to look at melatonin as a longevity molecule in itself (9-11). However, external melatonin supplementation can be problematic as it may disrupt your circadian rhythm and impede your body's natural ability to regulate this hormone - contributing to a ‘melatonin hangover’.

    Instead, Advanced Sleep Repair is engineered with a synergistic blend of L-tryptophan, vitamin B6, taurine and tart cherry extract that work together to support your body's natural melatonin production. L-tryptophan, an essential amino acid, is first converted into serotonin, a precursor to melatonin, which requires vitamin B6 (specifically in its active form, pyridoxal phosphate) as a coenzyme (12). This conversion is crucial, as serotonin is later transformed into melatonin (13).

    The tart cherry extract naturally contains trace melatonin and also aids in the production and availability of tryptophan in the body (14). The combined effect of these three elements – L-tryptophan providing the foundational amino acid, vitamin B6 facilitating its conversion to serotonin, and tart cherry extract enhancing both melatonin levels and tryptophan availability – boosts the body's production of melatonin, thereby potentially improving sleep quality and regulating sleep cycles naturally and more consistently (15). Finally, taurine stimulates the activity of an enzyme called pineal N-acetyltransferase, an additional booster of melatonin production (16).

  • OPTIMIZES NOCTURNAL DNA REPAIR

    ESSENTIAL FOR CELLULAR LONGEVITY

    Sleep is an invaluable restorative period when your body engages in various healing processes, including DNA repair. During this time, your metabolic rate decreases, creating an optimal environment for the activation of DNA repair mechanisms. Certain enzymes and proteins that detect and fix DNA damage work more efficiently during sleep, helping to rectify any DNA damage accumulated during waking hours (17).

    Advanced Sleep Repair incorporates crucial elements like magnesium and zinc to support these vital processes. Magnesium, acting as a cofactor for various repair enzymes, facilitates the biochemical reactions for repairing damaged DNA. Similarly, zinc plays a critical role in DNA synthesis and repair. It aids proteins in identifying DNA damage and mobilizing other proteins to initiate repair work. Inadequate zinc levels can impair these proteins' functioning, potentially leading to suboptimal DNA repair (18, 19).

    Additionally, taurine supplementation can decrease DNA damage by reducing the formation of 5-OH-uracil, 8-OH adenine and 8-OH guanine (20, 21). By bolstering the DNA repair mechanisms naturally activated during sleep, Advanced Sleep Repair promotes cellular longevity and enhances the body's resilience against age-related damage.

  • DEFENDS AGAINST OXIDATIVE STRESS

    REVITALIZES DAMAGE

    Oxidative stress, stemming from the production of harmful free radicals, accelerates tissue and cellular damage. This contributes to aging and various age-related conditions. As a significant part of nocturnal rejuvenation, the body uses sleep to combat the detrimental effects of oxidative stress. It achieves this by elevating the production of natural antioxidants, such as glutathione, which help neutralize free radicals during sleep (22).

    Advanced Sleep Repair is designed with this in mind, incorporating glycine, an essential component in the production of glutathione. By promoting the synthesis of this powerful antioxidant, glycine aids in mitigating oxidative stress during sleep and in safeguarding cellular health (23). Taurine, a naturally occurring amino acid, functions as a direct scavenger of reactive oxygen species (ROS), a primary type of free radical produced in the body (24). Additionally, taurine regulates crucial antioxidant enzymes, including superoxide dismutase and glutathione peroxidase, enhancing the body's inherent antioxidant defense system (25). Sour cherry extract, packed with crucial antioxidants, further helps diminish oxidative stress and protect against DNA damage, fortifying the body's natural defenses against age-accelerating oxidative damage (26, 27).

  • FORTIFIES COGNITIVE LONGEVITY

    SHARPER MENTAL PERFORMANCE, HEALTHIER BRAIN

    Advanced Sleep Repair is specifically formulated to support natural cognitive protective functions at night. It contains glycine, known for its powerful neuroprotective properties and benefits to memory and attention (28, 29), and L-theanine, which enhances concentration, supports brain health, and may slow down the aging processes in the brain (30-32). Additionally, magnesium and vitamin B6 synergistically work together to bolster brain health and function. Magnesium aids in neurotransmitter regulation and nerve signal transmission, protecting the brain from excitotoxicity, essential for cognitive processes (33). Vitamin B6 complements this effect by aiding neurotransmitter synthesis, including serotonin and dopamine, and regulating homocysteine levels, crucial in preventing cognitive decline (34). Together, they contribute to synaptic plasticity, essential for cognitive resilience and adaptation. This combination also helps reduce stress and improve sleep quality, both of which are vital for maintaining mental health over time (35, 36).

  • IMPROVED METABOLIC HEALTH

    WHILE YOU SLEEP

    A healthy metabolism is foundational for longevity. It ensures efficient conversion of nutrients into energy, promotes effective utilization of that energy for various bodily functions, and encourages proficient removal of metabolic waste. Maintaining a balanced metabolism can help prevent metabolic disorders such as diabetes and obesity, which can significantly impact lifespan. Advanced Sleep Repair is engineered to promote metabolic health during sleep (37).

    Taurine enhances insulin function and sensitivity for better blood sugar regulation, which is crucial in diabetes management. It also aids in cholesterol and fat metabolism, supporting cardiovascular health by helping regulate blood pressure and reducing the risk of heart diseases. Additionally, taurine is essential for liver health, assisting in detoxification and preventing fatty liver disease (38).

    Glycine plays a pivotal role in the synthesis of creatine, which is crucial for energy storage in cells and can improve insulin sensitivity in certain metabolic disorders, aiding glucose metabolism (39, 40). It may also stimulate autophagy - clearing damaged cellular components - via the derived metabolite sarcosine and aids in producing glutathione, an important antioxidant for cellular health. Glycine is also a component of collagen, necessary for connective tissue health (41).

    Magnesium contributes to enzyme function across carbohydrate, fat, and protein metabolism, aids in insulin regulation, and is crucial for ATP synthesis -the primary cellular energy source - necessary for optimal metabolic function (42, 43). Additionally, vitamin B6 supports amino acid metabolism and neurotransmitter synthesis, crucial for tissue repair and regulating sleep-related metabolic processes. It also helps maintain steady glucose levels overnight through glycogen breakdown (44).

  • MUSCLE, SKIN, AND JOINT REJUVENATION

    PROVIDES CRITICAL BUILDING BLOCKS FOR OVERNIGHT TISSUE REPAIR

    Sleep triggers a vital restorative phase for your body, increasing growth hormone production essential for tissue repair, including muscles, joints, skin, and bones. Advanced Sleep Repair enhances this rejuvenation process with its potent blend of glycine, magnesium, zinc, and sour cherry extract.

    Glycine is a powerhouse that supports muscle maintenance and repair, and is an essential component for collagen production - a key protein for skin, bone, and joint health (41, 45, 46). Magnesium aids in nerve and muscle function, bone health, and is another essential component for the synthesis of collagen (47).

    Sour cherry extract, abundant in antioxidants, boosts joint and muscle health, reduces inflammation, and is regularly used by elite athletes for post-exercise muscle recovery and repair (48, 49).

    Taurine helps regulate calcium levels in muscles, which are vital for muscle contraction and function. Adequate levels of taurine ensure efficient muscle performance and may help prevent cramping. Its anti-inflammatory properties also contribute to muscle recovery after exercise, reducing soreness and aiding in the repair of muscle tissue while you sleep (50).

    Lastly, zinc is an essential mineral for immune function, wound healing, and protein synthesis, all of which are crucial for maintaining healthy skin, muscles, and bones (51).

  • RESTFUL SLEEP, WITHOUT DEPENDENCY

    NON-SEDATIVES, SAFE FOR DAILY, LONG TERM USE

    Advanced Sleep Repair is designed to elevate sleep quality and encourage healthy sleep patterns, without fostering dependence. Unlike sleep sedatives that merely enforce a state of unconsciousness without addressing the root cause of sleep disturbances, Advanced Sleep Repair works to tackle the underlying issues. Insomnia, the most common sleep disorder, is largely psychological and often linked more to mental than physical health. Its treatment, therefore, requires cognitive-behavioral shifts rather than chemical intervention (52). Inducing sleep with chemicals can exacerbate insomnia by reinforcing the notion that sleep requires external aid (53).

    In contrast, Advanced Sleep Repair supports good sleep hygiene by foregoing a sedative approach to formulation altogether. Instead, it should be utilized safely and consistently alongside regular sleep-wake schedules, a conducive sleep environment, calming pre-sleep routines, balanced diet and exercise, and stress management. These habits help align the body's circadian rhythm, enhance sleep quality, and support natural transitions into sleep, leading to sustainable sleep improvements by addressing underlying issues (54). With Advanced Sleep Repair, you're not just sleeping better, you're sleeping smarter.

  • PROMOTES RELAXATION

    HELPS REDUCES STRESS

    The impact of stress on sleep quality and duration cannot be underestimated. The stress-induced "fight or flight" response interferes with our natural sleep-wake cycle, leading to disrupted sleep patterns and reduced restorative sleep. Advanced Sleep Repair offers a portfolio approach to foster relaxation, diminish stress, and provide mental tranquility, creating the serene state necessary for restful, rejuvenating sleep.

    Key ingredients such as theanine, GABA, and magnesium, work synergistically to achieve this. L-theanine, derived from tea leaves, promotes relaxation, eases stress, and soothes the mind (55-59). GABA is a natural neurotransmitter that reduces anxiety, promotes a sense of calm, and helps quiet the restless mind (60, 61). Magnesium contributes to stress reduction and tension relief, further fostering relaxation (62, 63).

    Vitamin B6 is essential for creating serotonin, the "feel-good" neurotransmitter, elevates mood and happiness. Additionally, vitamin B6 is involved in producing GABA, a neurotransmitter that induces relaxation and reduces nervous tension (64, 65).

    Muscle tension is a type of stress that can also interfere with sleep. Promoting muscle relaxation, magnesium, and glycine help reduce muscle stiffness, cramps, and restlessness, allowing for a more restorative and uninterrupted sleep (33, 66, 67), promoting overall sleep quality.

    Finally taurine's neuromodulatory role and its similarity to GABA can help diminish the neural activity associated with daily stress and anxiety. Since anxiety and stress are linked with increased brain activity, taurine's calming effect can make it easier to relax and fall asleep, thereby reducing the physiological symptoms of stress and anxiety (68, 69).

  • BALANCED NEUROTRANSMITTERS

    FOR PRECISION SLEEP & MOOD REGULATION

    Neurotransmitter balance is crucial for promoting good sleep. Balanced levels of serotonin, GABA, glycine, and other neurotransmitters help regulate the critical sleep-wake cycle. Maintaining proper neurotransmitter balance can improve sleep quality, making it easier to fall asleep, stay asleep, and wake up refreshed (70).

    Advanced Sleep Repair offers a synergistic precision protocol of L-theanine, GABA, vitamin B6 and glycine to support neurotransmitter balance. L-theanine and vitamin B6 promotes relaxation and has been found to increase neurotransmitters such as dopamine and serotonin levels, which are involved in mood regulation (65, 71).

    GABA acts as an inhibitory neurotransmitter, promoting a calming effect and helping to reduce anxiety and stress (61). Taurine acts as an inhibitory neurotransmitter in the brain, similar to GABA. This action can help calm the nervous system, promoting relaxation which is conducive to sleep (72). Vitamin B6 is additionally involved in the production of GABA (64).

    Glycine is an amino acid that functions as a neurotransmitter precursor, playing a role in synthesizing various neurotransmitters in the brain (41, 73). These ingredients can help support a healthy balance of neurotransmitters, vital for overall mental well-being and cognitive function.

How can sleep impact longevity?

Learn more

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Look inside

  • L-theanine

    L-theanine, an amino acid in tea leaves, is known for its calming effects. It enhances relaxation and sleep by increasing alpha brain waves, reducing anxiety, and promoting calmness, aiding sleep onset (55, 56). It improves deep sleep quality and reduces nighttime awakenings, benefiting mood and cognitive function. L-theanine appears to extend lifespan in some organisms by upregulating aging-protective proteins and antioxidative enzymes, aiding in managing glycation-induced crosslinks (74). It also boosts cognitive functions like focus and attention, particularly under stress (30). To get 400mg in our formula, you would need to drink 20 cups of green tea.
    formula

  • GABA

    GABA, a brain neurotransmitter, is key in regulating neuronal excitability and promoting relaxation. As an inhibitory neurotransmitter, it helps calm the mind. Studies show its potential in improving sleep quality and reducing insomnia. By binding to brain receptors, GABA reduces neuronal activity, aiding in falling and staying asleep. Supplementation may enhance sleep duration, shorten sleep onset time, and improve sleep quality. It also helps reduce anxiety and stress, which often disrupt sleep (60, 76). Trace amounts of GABA are present in soya products, fermented foods, and green tea.
    formula

  • Glycine

    Glycine, a non-essential amino acid, improves sleep quality by reducing sleep latency and enhancing sleep efficiency (77, 78). It helps regulate the sleep-wake cycle and has been shown to extend lifespan in various organisms, including multiple mammalian models. Glycine improves health in mammalian models of age-related diseases. It acts as an acceptor for Glycine N-methyltransferase, crucial for methionine clearance. Glycine's conversion to sarcosine has been known to induce autophagy, mimicking methionine restriction efforts, potentially aiding in longevity (37, 41). Its role in these biochemical pathways makes glycine beneficial for healthy lifespan extension.
    formula

  • Magnesium (amino acid chelate complex)

    Magnesium is a vital mineral that aids sleep regulation by activating the parasympathetic nervous system for relaxation and stress reduction. It assists in managing neurotransmitters and hormones like melatonin and GABA essential for sleep (62, 63, 80). Research suggests that magnesium supplementation can enhance sleep quality, lessen insomnia symptoms, boost sleep efficiency, and alleviate restless leg syndrome. Furthermore, magnesium promotes genomic stability, heart health, balanced blood sugar levels, and a healthy inflammatory response (43, 80). We leverage a chelated magnesium amino acid complex, among the most bioavailable and diverse forms of magnesium to help ensure superior absorption.
    formula

  • Vitamin B6 (pyridoxal-5-phosphate)

    Vitamin B6, as pyridoxal-5-phosphate, is crucial for numerous biochemical processes, including sleep health. It aids in synthesizing neurotransmitters like serotonin and GABA, vital for sleep regulation and relaxation (81). By facilitating L-tryptophan's conversion to serotonin, a precursor to the sleep-regulating hormone melatonin, it helps maintain healthy sleep patterns (12). When combined with magnesium, the effectiveness of pyridoxal-5-phosphate is enhanced. Magnesium activates vitamin B6 into its functional form, pyridoxal-5-phosphate, and together they improve neurotransmitter function and sleep quality (42, 82). To get the amount of Vitamin b6 found in Advanced Sleep Repair, you would have to consume around 1.7 kg of canned tuna.
    formula

  • Taurine

    Taurine, a naturally occurring amino acid found in the body, contributes to better sleep, combats oxidative stress, and potentially supports longevity. As a neuromodulator, it promotes relaxation and calmness, aiding restful sleep (72). Its antioxidant properties protect cells from damage linked to chronic diseases and aging, potentially contributing to longevity by preserving cellular health (24, 83). Studies show oral taurine supplementation in middle-aged mice significantly extended lifespan by 10-12% and improved life expectancy and organ function, including bone, muscle, pancreas, brain, fat, gut, and immune system (21). To get the equivalent amount of taurine present in Advanced Sleep Repair you would need to eat 2kg (4.4 pounds) of chicken breast.
    formula

  • L-Tryptophan

    An essential amino acid that serves as a precursor to serotonin, a neurotransmitter involved in regulating mood and sleep. L-Tryptophan has been studied for its potential sleep-enhancing effects, particularly in improving sleep latency (time taken to fall asleep) and sleep quality. By increasing serotonin and melatonin levels in the brain, L-tryptophan can help promote relaxation and contribute to more restful sleep (84, 85). L-tryptophan can be found in turkey and pumpkin seeds.
    formula

  • Tart Cherry Extract

    Tart cherry (Prunus cerasus) extract contains natural melatonin, key for regulating sleep-wake cycles and maintaining healthy sleep patterns. Studies show that tart cherry supplementation can boost melatonin levels, enhancing sleep quality, duration, and efficiency, while reducing insomnia symptoms and easing jet lag. Its natural melatonin makes it an effective option for natural sleep support (14, 86). Tart cherry extract is regularly used by elite athletes, as it may aid muscle regeneration, thanks to its anti-inflammatory and antioxidant properties (87).
    formula

  • Zinc

    It is an essential mineral that plays a role in numerous physiological processes, including sleep regulation. It synthesizes and metabolizes neurotransmitters, such as serotonin and melatonin, which are crucial for maintaining healthy sleep patterns. Zinc deficiency has been associated with sleep disturbances and insomnia. Supplementing with zinc may help improve sleep quality, reduce nighttime awakenings, and enhance overall sleep efficiency (88, 89).
    formula

How to use

Mix one scoop with one cup (8fl oz) water and drink before bedtime. It's recommended to avoid eating meals 2 hours before bed for the best results. Take Advanced Sleep Repair daily. For enhanced synergistic effects, combine with Longevity Foundation AM/PM.

+ behavioral protocol

Maintain a consistent sleep schedule and establish a calming bedtime routine. Reduce exposure to electronics prior to sleeping. Avoid stimulants and heavy meals before bedtime. Incorporate regular exercise into your routine, but avoid strenuous activity near bedtime. Manage stress with relaxation techniques. Keep daytime napping to a minimum. Refrain from consuming alcohol and nicotine before bed

+ WARNING

Not recommended for children, or for pregnant or nursing women. Before using, it's advised to consult a healthcare provider, particularly if you are taking medication or have chronic medical conditions. This product is not suitable for individuals who are allergic or hypersensitive to any component of the formula.

Sleep is the single most effective thing we can do to reset our brain and body health each day: Mother Nature's best effort yet at contra-death

Matthew Walker, Author of Why We Sleep: Unlocking the Power of Sleep and Dreams

Scientific studiеs

  • Glycine improved subjective sleep quality and sleep efficacy.

    The effects of taking glycine (3 g) before bedtime were examined in a study on individuals with unsatisfactory sleep. The results showed that glycine improved subjective sleep quality and efficacy (sleep time divided by time spent in bed). It also reduced the time to fall asleep and reach slow-wave sleep without affecting the overall sleep architecture. Additionally, glycine reduced daytime sleepiness and enhanced performance in memory recognition tasks. These findings suggest that when ingested before bedtime, glycine can improve subjective and objective measures of sleep quality in a manner different from traditional hypnotic drugs like benzodiazepines (90).

  • Glycine helps maintain healthy cognition and brain aging

    The effects of Bioglycin, a form of glycine that interacts with the N-methyl D-aspartate receptor complex, were studied in young and middle-aged individuals to assess attention, memory, and mood. In a double-blind, randomized, crossover study, healthy students (mean age, 20.7 years) and middle-aged men (mean age, 58.9 years) were tested. The middle-aged group showed poorer verbal episodic memory, attention, and subjective responses compared to the young group. Bioglycin improved episodic memory in both groups and enhanced sustained attention in middle-aged men. Unlike other cognitive enhancers, Bioglycin lacked stimulant properties, had no significant effects on mood, and primarily improved memory rather than attention. It may be beneficial for situations requiring high retrieval of information or when performance is affected by factors like jet lag, shift work, or disrupted sleep (29).

  • Glycine and Aging: Evidence and Mechanisms

    The simple amino acid glycine extends lifespan in worms, mice, and rats. Glycine also improves aspects of health in mammalian models of age-related disease. Glycine is the acceptor for GNMT, an enzyme responsible for methionine clearance. GNMT also converts glycine to sarcosine, an autophagy-inducing metabolite. Glycine may prolong life by inducing autophagy and mimicking methionine restriction.

  • L-theanine in green tea as potential shield from dementia and stress-induced aging.

    Slowing brain aging is crucial for preventing dementia, as aging is the primary risk factor. Green tea catechins (GTCs) have potent antioxidant activity and can reduce oxidative damage, brain atrophy, and cognitive decline in aged mice. Ingesting GTCs or drinking green tea at a middle-aged stage can suppress age-related cognitive decline. Chronic stress accelerates brain aging, but L-theanine, an amino acid in green tea, can mitigate stress-induced aging. Regular consumption of green tea is beneficial in slowing brain aging, and theanine-rich green tea or low-caffeine green tea may help suppress stress and stress-induced aging (93).

  • L-Theanine protects against DNA damage

    The study investigated the protective effect of L-theanine against irinotecan-induced DNA damage in mouse bone marrow cells. L-theanine, given at doses equivalent to 30 or 60 mg/kg for 12 days, showed no genotoxic or cytotoxic effects. Pretreatment with L-theanine reduced irinotecan-induced genomic damage in bone marrow cells in a dose-dependent manner. Irinotecan caused oxidative DNA stress, but L-theanine administration mitigated these effects by modulating cellular antioxidant levels. The findings suggest that L-theanine has a protective role in preventing irinotecan-induced DNA damage in mouse bone marrow cells (94).

  • GABA/L-theanine mixture has a positive synergistic effect on sleep quality and duration

    The GABA/L-theanine mixture decreased sleep latency and increased sleep duration compared to GABA or L-theanine alone. REM and NREM sleep were significantly increased with the combination, indicating improved sleep quality. The mixture restored normal sleep time and quality in an animal model of caffeine-induced awareness. The increased expression of GABA and the glutamate GluN1 receptor subunit suggests that the GABA/L-theanine combination has neuromodulatory effects on sleep behavior (61).

  • Magnesium crucial in maintaining genomic stability (a Hallmark of Aging).

    Magnesium is an essential element involved in various metabolic pathways and plays a crucial role in maintaining genomic stability. It is not genotoxic and helps stabilize DNA and chromatin structure. Magnesium serves as a cofactor in enzymatic systems responsible for DNA processing, ensuring high fidelity during DNA replication and facilitating DNA damage repair. Intracellular magnesium levels are tightly regulated and contribute to cell cycle control and apoptosis. Magnesium deficiency can affect membrane integrity, increase susceptibility to oxidative stress, and be linked to cardiovascular diseases and accelerated aging. The relationship between magnesium and tumor formation is complex, as it may have protective effects at early stages but promote tumor growth later on. Marginal magnesium deficiencies are common due to inadequate daily intake in many industrialized countries, falling below recommended dietary allowances (17).

  • Supplementation with magnesium reduces oxidative DNA damage

    This study aimed to assess the impact of four-week magnesium supplementation on DNA integrity in individuals with sedentary lifestyles and rugby players. Sedentary lifestyle is associated with increased risks of cardiovascular disease, obesity, and type 2 diabetes, while strenuous exercise can induce oxidative stress and DNA damage. Using the comet assay, the study found that rugby players had significantly higher levels of DNA damage in peripheral blood lymphocytes compared to sedentary students. However, magnesium supplementation reduced the number of cells with high DNA damage in both groups when exposed to H2O2, and in rugby players, it also reduced the number of cells with medium DNA damage. These findings suggest that four-week magnesium supplementation can protect DNA from oxidative damage in both sedentary individuals and rugby players (95).

  • Taurine deficiency as a driver of aging.

    Taurine, a semi-essential micronutrient abundant in humans and other eukaryotes, emerges as a potential influencer in the aging process. Research indicates that taurine levels in the blood decrease with age in various species, including mice, monkeys, and humans. Notably, administering taurine orally to middle-aged C57Bl/6J mice led to a visible extension in their median lifespan by 10 to 12% and an increase in life expectancy at 28 months by approximately 18 to 25%. This treatment also significantly enhanced their overall health, as evidenced by improved organ functionality. Similar benefits in health span were observed in monkeys. While taurine's impact was not significant in unicellular yeast, it did extend the lifespan of multicellular worms. The supplementation of taurine positively influenced several critical aspects of aging, such as reducing cellular aging, defending against deficiencies in telomerase, lessening mitochondrial dysfunction, curbing DNA damage, and diminishing inflammation. In humans, lower levels of taurine and related compounds correlate with various health problems, including obesity, hypertension, inflammation, and diabetes. Additionally, exercise was found to elevate levels of taurine metabolites, potentially linking physical activity's anti-aging benefits to taurine (21).

  • L-Tryptophan supplementation can help improve sleep quality.

    This study aimed to assess the effect of L-tryptophan (Trp) supplementation on sleep quality by analyzing existing research through a meta-analysis. Sleep disturbances have been linked to various health conditions, so understanding the impact of Trp on sleep is essential. A total of 18 articles were collected and analyzed for sleep outcomes such as total sleep time, sleep latency, wake after sleep onset and sleep efficiency. The results indicated that Trp supplementation can reduce wake-after-sleep onset (WASO). The analysis also revealed that a Trp dose of at least 1g was more effective in lowering WASO compared to a dose below 1g. However, Trp supplementation did not show significant effects on other sleep components. In conclusion, Trp supplementation, particularly at 1g or more doses, can help improve sleep quality (15).

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Science-Backed Ingredients backed by hundreds of studies, reviewed by leading longevity experts
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Cutting Edge Flexible supply chain that rapidly adapts formulas to the latest longevity science

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More than just a supplement, each product is a complete protocol and lifestyle program, synergistically formulated to work best together, and with ongoing use. 

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FAQ’s

  • What is Advanced Sleep Repair?

    Advanced Sleep Repair is a carefully formulated dietary supplement that supports healthy sleep patterns, promotes a restful night's sleep, and helps enhance the age-rejuvenation properties of sleep. In essence, it aims to support deep sleep as well as amplifying regenerative mechanisms that occur during sleep.

  • How does Advanced Sleep Repair work?

    Advanced Sleep Repair combines key ingredients such as L-theanine, GABA, glycine, magnesium, vitamin B6, L-tryptophan, sour cherry extract, and zinc to promote relaxation, support neurotransmitter balance, regulate body temperature, and provide natural melatonin. It also provides ingredients that relate to essential overnight repair and renewal mechanisms. These components work synergistically to help calm the mind, ease stress, optimize sleep quality, and enhance the longevity therapeutic properties of sleep.

  • How should I take Advanced Sleep Repair?

    Mix one scoop with one cup (8fl oz) water and drink before bedtime. It's recommended to avoid eating meals 2 hours before bed for the best results. Take Advanced Sleep Repair daily. For enhanced synergistic effects, combine with Longevity Foundation AM/PM.

  • Is Advanced Sleep Repair suitable for everyone?

    Advanced Sleep Repair is generally well-tolerated, but individual responses may vary. However, its not recommended for children, or for pregnant or nursing women. It is important to consult with your healthcare professional before starting any new supplement regimen, especially if you have any underlying medical conditions, are taking medications, are pregnant, or are breastfeeding. Of course, this product is not suitable for individuals who are allergic or hypersensitive to any component of the formula.

  • Can I become dependent on Advanced Sleep Repair for sleep?

    Advanced Sleep Repair is not habit-forming or addictive when used as directed. It is intended to support healthy sleep patterns and promote a restful night's sleep without causing dependency. Following the recommended dosage and consult with your healthcare professional is always advisable.

  • How long does it take for Advanced Sleep Repair to work?

    The effects of Advanced Sleep Repair may vary among individuals. While some individuals may experience noticeable improvements in sleep quality and relaxation on the first night, others may require more time to observe the full benefits. Consistency in use and adherence to healthy sleep habits are key to achieving optimal results.

  • How can I enhance the effectiveness of Advanced Sleep Repair?

    Maintain a consistent sleep schedule and establish a calming bedtime routine. Reduce exposure to electronics prior to sleeping. Avoid stimulants and heavy meals before bedtime. Incorporate regular exercise into your routine, but avoid strenuous activity near bedtime. Manage stress with relaxation techniques. Keep daytime napping to a minimum. Refrain from consuming alcohol and nicotine before bed.

  • I experience excessive overnight urination, and I'm concerned that drinking a cup of this product will disturb my sleep. What should I do?

    We understand your concern about overnight urination, especially when it comes to drinking fluids before bedtime. Our product is designed to provide therapeutic benefits, but we recommend adapting its consumption to suit your individual needs and comfort.

    One effective approach is to consume the drink 30 to 60 minutes before your bedtime. This timing allows your body enough time to process the liquid and significantly reduces the likelihood of nighttime disruptions. Additionally, you might consider limiting other liquids before bed to make up for this, or starting with a smaller amount of the drink to assess your body’s response and gradually increase to the recommended serving size as you become more comfortable with its effects.

    Remember, it’s important to maintain a balance between getting the benefits of our product and ensuring a good night's sleep. Adjusting the timing of consumption could be a key factor in achieving this balance. If you continue to experience concerns, we recommend consulting with a healthcare professional to discuss your specific situation and needs.

References

  1. Reference link

    1. Baugh A, Buhr RG, Quibrera P, Barjaktarevic I, Barr RG, Bowler R, et al. Risk of COPD exacerbation is increased by poor sleep quality and modified by social adversity. Sleep. 2022;45(8).

  2. Reference link

    2. Libman E, Fichten C, Creti L, Conrod K, Tran D-L, Grad R, et al. Refreshing sleep and sleep continuity determine perceived sleep quality. Sleep Disorders. 2016;2016.

  3. Reference link

    3. Reed DL, Sacco WP. Measuring sleep efficiency: what should the denominator be? Journal of clinical sleep medicine. 2016;12(2):263-6.

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