FASTING
Fasting Tonic™
Fasting Tonic™
Fasting Tonic™
Fasting Tonic™
Fasting Tonic™
FASTING

Fasting Tonic™

Fasting and caloric restriction are among the most potent lifestyle hacks for longevity, yet they’re also hard and pose significant challenges. Enter Fasting Tonic™ - a groundbreaking precision drink mix engineered to ease and enhance your fasting experience. The innovative formula is built around natural micro-beadlets that expand into prebiotic jelly in your stomach, helping you feel full (literally!) without chemicals or caffeine, while healing the gut, all without breaking your fast. Fasting Tonic™ goes beyond mere appetite management. It replenishes vital micronutrients and electrolytes lost during fasting, ensuring optimal hydration and combating fatigue. Plus, it's crafted to safeguard against muscle loss, a major concern with fasting routines, making it a comprehensive ally for your fasting journey.

  • support fasted exercise
  • source of energy
  • prevent muscle atrophy
40 capsules (20 doses) of each per order
Subscribe and save 25%. Subscription details.
Fasting Tonic™
Ingredients
Vitamin D (as cholecalciferol)
3.1 mcg (125 IU)
Calcium
50 mg
Magnesium (as magnesium citrate)
25 mg
Chloride (as sodium chloride and potassium chloride)
190 mg
Sodium (as sodium chloride)
75 mg
Potassium (as potassium chloride)
90 mg
Glucomannan (konjac root)
1500 mg
Creatine monohydrate
1000 mg
Calcium HMB (Calcium 3-Hydroxy-3-Methylbutyrate monohydrate)
375 mg
Aquamin™ mineralized seaweed
10 mg

Revolutionize fasting, without breaking your fast

Precision-engineered nutrient matrix for easier fasting, peak performance, and added safety

Why it’s different

  • Fasting and caloric restriction

    for whole body health

    Harness the transformative power of fasting and caloric restriction, powerful longevity lifestyle hacks celebrated for their whole-body health benefits. These practices, involving reduced caloric intake without sacrificing essential nutrients, extend beyond mere weight loss (1). They positively modify cholesterol levels, lowering LDL and boosting HDL to reduce heart disease risk, support glucose balance, elevate ketone levels, and reduce inflammation and oxidative stress (2, 3). Remarkably, prolonged caloric restriction, as demonstrated by a major Columbia University study, can even slow down the aging process (4). At the core of these benefits is 'hormesis', nature's secret to longevity. This natural response, triggered by dietary stressors like fasting, activates protective cellular mechanisms, including stress responses and autophagy (5, 6). Autophagy, in particular, is critical for longevity, removing damaged cells to promote cellular renewal (7).

    "Intermittent fasting definitely and massively increases autophagy. And thanks to our caveman history, it thrived. In times of little food, lysosomes would race around the body looking for damaged cells, pre-diseased cells, and cells which weren't doing much. It would chop them apart – into their smallest parts – and either burn them for energy, or use them to repair other areas. Simply, it would perform miracles without any outside help." – Robert Skinner, author of 'The IF diet'.

  • Trick Hunger, Stay Full Naturally

    without breaking a fast

    Fasting and caloric restriction can make you hungry and cranky. But Fasting Tonic™ is here to help quench your hunger naturally, without caffeine, chemicals, or other stimulants. Our formula is engineered around powerful glucomannan micro-beadlets, a natural, soluble dietary fiber derived from the konjac plant root, known for its impressive ability to promote satiety. It expands in your stomach, absorbing up to 50 times its weight in water, creating a sensation of fullness without adding calories or nutritional value, thus maintaining the integrity of your fast (10, 11).

    Over time, this could contribute to weight loss or weight management, associated with reduced risk of many chronic diseases and potentially longer life expectancy. Glucomannan can also slow the absorption of sugar in the gut, which can help to control blood sugar levels, and it lowers total cholesterol, low-density lipoprotein cholesterol and triglycerides, and to a lesser extent, raises high-density lipoprotein cholesterol (12). Improved lipid profiles can contribute to better cardiovascular health, a factor essential for longevity (13, 14).

  • Replenish vital micronutrients

    depleted during fasting

    During fasting, essential electrolytes such as sodium, potassium, chloride, calcium, and magnesium can be significantly depleted (partially through excretion, but also through a lack of food intake), leading to symptoms like headaches, muscle cramps, fatigue, and even blood pressure irregularities (15, 16). Fasting Tonic™ is meticulously formulated to counter these deficiencies by replenishing these vital nutrients, ensuring a more comfortable fasting experience without common side effects.

    Our comprehensive blend includes Aquamin™ mineralized seaweed (17, 18) a rich source of crucial trace minerals, as well as sodium, potassium chloride, and magnesium citrate - essential electrolytes. Sodium and potassium are essential for maintaining fluid balance, nerve and heart function, and muscle contractions (19). Magnesium and calcium play pivotal roles in energy production, nerve function, muscle contraction, as well as supporting heart and bone health (20).

    Magnesium, especially, is vital during fasting as its deficiency is common and can be exacerbated by fasting. As an essential mineral, magnesium aids in enzymatic reactions, energy production, membrane function, regulation of calcium and potassium, and supports cardiac and brain function. Most people are at risk of subclinical magnesium deficiency even when not fasting, and this risk increases during a fast. The kidneys may excrete magnesium at a rate up to 4-5 times higher than normal during prolonged fasting - this loss can be significant, with average magnesium losses per day in some studies ranging from 83 mg to 203 mg. Fasting Tonic™ delivers an optimal amount of these electrolytes, particularly magnesium, to support your body’s needs during fasting, helping you fast safely and effectively while nourishing your body at a cellular level for a healthier fasting experience (21).

  • Preserve Muscle Mass

    Even during fasted exercise

    Fasting, though healthful, can sometimes lead your body to use muscle as a fuel source. Additionally, from age 30, we start to lose 1-2% of muscle mass each year, which can increase injury risk and impact metabolic health (22). The impact of fasting on muscle mass can be complex. While short-term fasting might not significantly affect muscle mass, prolonged periods without adequate nutrition can lead to muscle breakdown as the body seeks alternative energy sources (23). Fasting Tonic™ is expertly designed to protect your muscles and maintain strength during these practice.

    Fasting Tonic™ is engineered with creatine, a naturally occurring compound that replenishes muscle fuel and enhances muscle mass, even during fasting (24, 25). Creatine assists in ATP regeneration, crucial for maintaining muscle function without breaking your fast, and helps increase muscle cells' water content, a process known as cell volumization, offering an anabolic (muscle-building) effect that helps retain muscle mass further during times of stress.

    Additionally, Fasting Tonic™ features calcium β-hydroxy β-methylbutyrate (Ca-HMB), derived from the amino acid leucine, which is known to reduce muscle breakdown and support muscle maintenance during fasting (64). It can also aid in recovery and performance. Fasting may reduce physical performance due to lower energy availability, but Ca-HMB can mitigate this by speeding up recovery after intense exercise (26-29). Vitamin D3 is essential for maximizing the effectiveness of myHMB®, making the combination of Ca-HMB and Vitamin D a potent resource for achieving optimal muscle health and functionality (30). The synergistic combination of creatine and myHMB® is a powerful duo to help embrace fasting confidently, knowing your muscle health is supported and your body is ready for peak performance. This combination can be particularly effective for those looking to safely combine fasting with a workout regimen.

  • Helps Maintain a Healthy Weight

    for Healthy Longevity

    Achieving and maintaining a healthy weight is a cornerstone of longevity. Fasting Tonic™ is formulated with ingredients that support weight management efforts as part of your fasting regimen. Glucomannan, a dietary fiber, plays a pivotal role by promoting a feeling of fullness. This can lead to a natural reduction in calorie intake and assist in weight loss (10, 11, 31). As glucomannan expands in the stomach, it reduces the urge to overeat, making it easier to manage portion sizes and reduce overall caloric consumption. Additionally, the inclusion of essential minerals like calcium, magnesium, and potassium helps in maintaining electrolyte balance. This is important during fasting as changes in eating patterns can disrupt the body's natural electrolyte levels, potentially affecting hydration and metabolism, which are critical factors in healthy weight management (16, 19, 32). Creatine and Ca-HMB also contribute to this goal. While primarily known for enhancing muscle strength and performance, these compounds have been shown to support a leaner body composition by promoting muscle mass (33), and reducing body fat (64), during times of fasting. Higher muscle mass can lead to an increased metabolic rate, which helps in burning more calories, even at rest. This makes it easier to achieve and maintain a healthy weight over the long term. Together, these ingredients in Fasting Tonic™ offer a synergistic approach to weight management.

  • Eases transition to eating

    Skip the Post-Fast Crashes

    Transitioning from fasting to eating can often lead to intense cravings and overeating, causing rapid blood glucose spikes that can undo the benefits of fasting. Fasting Tonic™ eases this transition by featuring a unique fibrous jelly that moderates hunger and slows food absorption in the digestive track, ensuring a gradual increase in blood glucose and preventing insulin spikes which are detrimental to healthy longevity (11, 34). The addition of creatine monohydrate in our formula supports sustained muscle energy production, further protecting against post-fast crashes (33, 35). With Fasting Tonic™, transitioning from fasting to eating becomes a smooth, stress-free process.

  • Revitalize Gut Microbiome

    Defy Dysbiosis

    The gut microbiome is a vibrant community of microorganisms in your gut. Over time, this balance can be thrown off, leading to gut dysbiosis—a major contributor to aging. Intermittent Fasting has been shown to revamp your gut microbiome, boosting its diversity and promoting the reorganization of microbes. Fasting Tonic™ amplifies these benefits. Infused with glucomannan-based micro-beadlets, a potent prebiotic that nourishes your gut's microorganisms validated by human trials (36). These prebiotics are like a gourmet feast for essential microrganisms. Firstly, they boost the growth of beneficial bacteria and fungi, crucial for digestion, nutrient absorption, immune function, and even mood regulation (37-39). Then, these beneficial bacteria turn glucomannan into essential elements for healthy digestion, such as sodium butyrate, which helps in repairing and strengthening the gut lining. By preventing leaky gut syndrome (where gut microbiota may leak into the bloodstream causing inflammation that accelerates aging), glucomannan plays a vital role in maintaining gut integrity, helping to reduce inflammation, and thereby enhancing overall well-being during fasting. But that is not all. AquaminTM mineralized seaweed contributes to gut health by protecting probiotic bacteria from the acidic conditions in the stomach. Rich in calcium, it has demonstrated effects similar to prebiotics on gut microbiota, leading to notable shifts in the production of lactate and short-chain fatty acids (40).

  • Maintain peak hydration

    for safer fasting

    Hydration is key during fasting, as about 20% of our daily fluid intake typically comes from food, which further offers essential nutrients to help our bodies hold onto water. Without these nutrients, the water we consume can simply pass through our bodies, potentially leading to dehydration (41). That is where Fasting Tonic™ steps in with a multi-prong approach to keep your body, organs, and cells hydrated.

    Firstly, Fasting Tonic™ is a deliciously designed water-based drink that gives you your baseline boost for hydration. Next, the creatine in our tonic helps muscle cells hold onto water, thereby improving your body's overall hydration (42). Beyond this, our tonic includes vital electrolytes—sodium, potassium, calcium, chloride and magnesium—that regulate your body's fluid balance. Sodium prompts your body to retain water, while potassium works in concert with sodium to manage cellular water levels. Together, they keep your body hydrated, stave off muscle cramps, and ensure the proper functioning of nerves and muscles (15, 43-45). With Fasting Tonic™, you can maintain peak hydration levels even while fasting—fueling your overall health.

  • Choose Fasting or Calorie Restriction

    Tailor to your lifestyle

    Fasting Tonic™ offers the flexibility to support both intermittent fasting and calorie restriction lifestyles. For those practicing intermittent fasting, it can be consumed during your fasting windows, aiding in hunger management without breaking your fast. Its glucomannan content helps in creating a feeling of fullness, while essential nutrients and electrolytes maintain your body’s balance. If calorie restriction is more your style, Fasting Tonic™ works throughout the day, even alongside meals. It helps achieve satiety, assisting you in managing portion sizes and reducing overall calorie intake. This flexibility allows you to experiment and personalize your approach to longevity, tailoring it to suit your unique lifestyle and goals. Whether you’re an intermittent faster or prefer calorie restriction, Fasting Tonic™ adapts to your needs, supporting your journey towards a healthier, longer life.

How can calorie restriction diets affect the 12 hallmarks of aging?

Learn more

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Look inside

  • Glucomannan

    Glucomannan, an extraordinary, highly soluble fiber from konjac root, supports fasting and longevity by creating a sensation of fullness, aiding in appetite control and weight management. It can absorb up to 50 times its weight in water, forming a gel-like substance in the stomach and creating a natural sensation of fullness. Research has shown that it can help keep blood glucose levels steady, a critical factor in staving off insulin resistance and healthy longevity (13). Additionally, it's heart-healthy, potentially lowering cholesterol and reducing cardiovascular disease risk. As a prebiotic, it nourishes gut bacteria, promoting a balanced microbiome linked to longer lifespan (38).
    formula

  • Magnesium

    Magnesium plays a key role in energy production, bone health, and muscle function. Its importance is heightened during fasting or intermittent fasting, where it aids in energy production, maintains electrolyte balance, prevents muscle cramps, and supports mood and sleep. Beyond fasting, maintaining optimal magnesium levels is linked to a reduced risk of chronic diseases, contributing to longevity. Magnesium is so crucial for life that it is found in every single cell in the human body. (51-53).
    formula

  • Ca-HMB (Calcium β-hydroxy-β-methylbutyrate)

    Calcium β-hydroxy-β-methylbutyrate (Ca-HMB), naturally produced from leucine metabolism in protein-rich foods, is popular in fitness and bodybuilding. Research is examining its benefits for healthy aging and longevity (28). Ca-HMB stimulates protein synthesis and prevents muscle breakdown, aiding in combating muscle loss due to aging and benefiting athletes and active individuals by maintaining or increasing muscle mass (26-29, 54). Jung+ boosts its effectiveness by adding Vitamin D, further enhancing its impact (30).
    formula

  • Creatine

    Among the most studied compounds on earth, creatine, naturally produced from amino acids, is increasingly regarded as a potential longevity molecule. During fasting, it provides immediate energy for high-intensity activities, helping maintain physical performance (56). Supplementing with creatine boosts muscle mass and strength, essential for health and independence in aging (57). It also supports cognitive function, offering potential protection against neurodegenerative diseases like Parkinson's and Alzheimer's (58). Additionally, creatine aids in bone health, with long-term supplementation and resistance training improving bone mineral density in older adults (59). While found in milk, red meat, and seafood, you would need to drink 30 liters/7.9 gallons of milk to get an equivalent in one serving of Fasting Tonic™.
    formula

  • Sodium, potassium, Chloride

    Sodium, potassium, and chloride, key electrolytes, are crucial during fasting and for longevity. In fasting, they maintain electrolyte balance; sodium helps retain water while, together with potassium and chloride, regulates cellular water levels for hydration (43, 45). Potassium, vital for a healthy heartbeat and muscle function, is the body's third most abundant mineral. Sodium controls blood volume and pressure, essential for muscle and nerve function (48). A potassium-rich diet may reduce cardiovascular disease risk, important for healthy aging (19, 49). Proper sodium, potassium, and chloride balance also ensures stable kidney function, contributing to longevity (50).
    formula

  • Aquamin™ mineralized seaweed

    Aquamin™, derived from the red algae Lithothamnion in the North Atlantic, is a natural multi-mineral supplement noted for its high calcium content and trace minerals like magnesium, iron, and zinc. Its uniqueness lies in the high bioavailability of these minerals, thanks to the algae's natural mineral absorption process (47). Aquamin™ supports bone health with its calcium richness and also benefits joint health, digestive wellness, and reduces inflammation. It contains at least 12% calcium, making it a potent supplement for various health needs (18, 40).
    formula

How to use

Mix one scoop with one cup (8fl oz) of water, and consume promptly to avoid premature clumping. Always apply a ratio of one scoop of Fasting Tonic™ per cup of water: for additional servings, mix a new scoop with another cup of water to maintain ratio. Once consumed, Fasting Tonic™ will expand into a thick gel, helping your stomach feel full. Every stomach is different in size, so you can take more than one serving for desired effects. However, limit to four (4) servings per day.

+ ADDITIONAL TIPS

For Intermittent Fasting Regimens: consume individual servings throughout your fasting window. For Calorie Restriction Diets: consume individual servings between and also before meals. For Healthy Weight Management: consume individual servings between and before meals.

+ WARNING

Not recommended for children, pregnant, or nursing women. Consult a healthcare provider before use, especially if you are on medication or have chronic medical conditions. This product is not suitable for individuals with kidney disease, high blood pressure, liver disease, or for those allergic or hypersensitive to any component of the formula. Discontinue use and seek medical advice if you experience adverse effects. It is absolutely essential to ensure adequate overall nutritional and food intake with any fasting regimen.

Intermittent fasting is incredibly useful in aiding fat loss, building muscle, and increasing resilience. Done correctly, it's one of the most painless high-impact ways to live longer.

Dave Asprey, American author and speaker. Known as the father of biohacking.

Scientific studiеs

  • Effects Of Intermittent Fasting On Disease Processes And General Health

    Intermittent fasting (IF) and periodic fasting (PF) are gaining recognition as safe approaches to enhance longevity and improve overall health by targeting cellular aging and disease risk factors while exhibiting minimal side effects. Intermittent fasting, lasting anywhere from 12 to 48 hours and practiced once every 1 to 7 days, as well as periodic fasting, lasting 2 to 7 days and performed once per month or less frequently, can potentially prevent and treat various diseases. This article overviews the different fasting strategies and their effects on longevity across various organisms, from yeast to humans. It establishes connections between fasting and the primary nutrient-sensing signaling pathways, emphasizing the advantages of fasting and refeeding periods. Additionally, it examines the therapeutic potential of IF and PF, specifically focusing on cancer, autoimmunity, neurodegeneration, and metabolic and cardiovascular diseases. We also address the potential side effects of IF and PF (7).

  • Impact of Electrolyte Supplementation on Fluid Balance and Athletic Performance During Intense Exercise

    Water, comprising 60-70% of the human body, is vital for maintaining homeostasis and distributing essential nutrients like minerals, vitamins, and electrolytes. Proper hydration, influenced by factors like gender, environment, diet, and physiological processes, is particularly crucial during exercise to maintain electrolyte balance and prevent dehydration-related health issues such as increased blood viscosity and reduced oxygen delivery. During physical activities, hormones like ADH and aldosterone regulate water and electrolyte levels, but hydration with plain water alone can risk hyponatremia, leading to confusion and seizures. In a study comparing regular water with an electrolyte drink (3RINK) on exercise performance and recovery, 10 young men exercised on a treadmill and consumed either fluid before and after exercising. Results showed higher total body, intracellular, and extracellular water levels with 3RINK consumption post-exercise. While no significant changes were found in certain hormones, differences in hematocrit and sodium levels were noted based on the fluid type. The study concluded that electrolyte intake before and after exhaustive exercise enhances water retention, and exercise capacity, and reduces fatigue more effectively than water (61).

  • Different Dietary Fibers Remodel Gut Microbiota And Charge Up Anti-Obesity Effects

    This study explored the effects of dietary fiber supplementation on gut microbiota and associated metabolites in relation to obesity indicators. In a 12-week double-blind, placebo-controlled trial with 53 overweight or obese adults, participants were randomly assigned to consume either a pea fiber supplement or a control. Blood and fecal samples were analyzed at the start and end of the trial. The study revealed that fiber significantly altered fecal short-chain fatty acids (SCFAs) and bile acids, with increased acetate levels and decreased levels of several bile acids. Gut microbiota was also differentially modulated, with an increase in SCFA producer Lachnospira in the pea fiber group, and a decrease in the control group. Notably, the change in participant body weight negatively correlated with their change in Lachnospira abundance. This study shows how pea fiber may influence the interaction between gut microbiota and host metabolism in obesity (62).

  • Supplementation with Ca-HMB and vitamin D3 enhanced muscle function and strength in older adults.

    This study aimed to assess if supplementation with calcium β-hydroxy-β-methylbutyrate (HMB) and vitamin D3 could improve muscle function and strength in older adults. Participants over 60 years old with low vitamin D levels were randomly assigned to four groups: control with no exercise, HMB+D with no exercise, control with exercise, and HMB+D with exercise. The study found that HMB+D supplementation significantly improved lean body mass and knee extension peak torque in non-exercising participants at 6 and 3 months, respectively. Furthermore, HMB+D supplementation improved a composite functional index, including handgrip, Get Up, and Get Up and Go measurements changes, in non-exercising participants at 3, 6, and 12 months (30).

  • Creatine As An Energy Source And Muscle Loss Prevention Agent During Fasting

    This study investigated the effects of creatine supplementation during a period of energy restriction in male resistance trainers. The participants were given a diet of 75.3 kJ (18 kcal) x kg(-1) x d(-1) (54.7% carbohydrate, 21.3% protein, and 24.0% fat) for four days. Creatine supplemented group demonstrated significant increases in muscle total creatine and creatine phosphate of 15-16% over the energy restriction period, whereas the placebo group had no changes in muscle creatine. Although both groups saw similar decreases in body weight and body fat percentage, the difference in fat-free mass was smaller in the creatine group. Furthermore, when adjusted for body weight, total work done during the sprints showed a trend toward being 3.8% higher in the creatine group. This suggests that creatine supplementation during short-term energy restriction might increase muscle creatine levels and potentially enhance sprint performance (63).

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FAQ’s

  • I plan a prolonged fast (multiple days). Can I use Fasting tonic?

    Fasting Tonic™ is designed to support the body during fasting periods, including prolonged fasts. However, prolonged fasting can have significant health implications and should always be undertaken with the guidance of a healthcare provider. It is recommended to discuss your plans with a healthcare provider and ask if Fasting Tonic™ is a suitable support during your fast.

  • How many servings of Fasting tonic a day I could take?

    Once consumed, Fasting Tonic™ will expand into a thick gel, helping your stomach feel full. However, every stomach is different in size, and you may choose to take more than one serving for desired effects. It's recommended to limit to four (4) servings per day.

  • Can Fasting Tonic™ cause upset stomach?

    Bloating, flatulence, soft stools, or diarrhea can be a side effects of any dietary fiber, such as the glucomannan in the formula. But those effects are uncommon. If you experience any worrying effects, please consult your doctor.

  • Can I take Fasting Tonic™ during a ketogenic diet?

    Yes, Fasting Tonic™ is designed to support the body during periods of low carbohydrate intake, such as fasting or following a ketogenic diet. As always, it is recommended to consult with a healthcare provider before starting any new supplement regimen.

  • Will this break my fast?

    No. Fasting Tonic™ has been formulated with ingredients that provide no nutritional value that would interfere with a fast.

  • How do I use this for Calorie Restriction or Weight Management?

    Fasting Tonic™ has been designed for more than just intermittent fasting. For Calorie Restriction Diets or Healthy Weight Management, our recommendation is similar: consume individual servings between and before meals. Once consumed, Fasting Tonic™ will expand into a thick gel, helping your stomach feel full. This should help you eat less, on the whole, throughout the day, helping you cut calories and maintain a healthy weight. But if you plan to reduce calories, its essential to ensure you're still getting enough macro and micro nutrients to maintain optimal health.

  • I want something stronger - can I use two scoops in my cup?

    No. Always apply a ratio of one scoop of Fasting Tonic™ per cup of water: for additional servings, mix a new scoop with another cup of water to maintain ratio.

  • I'm new to fasting. Do you have any advice?

    Begin with shorter fasting periods and gradually extend them. Ensure regular hydration by drinking water, as the tonic is a supplement, not a replacement for your fluid needs. When breaking your fast, opt for light, digestible meals, and monitor your body's response. Discontinue use and seek medical advice if you experience adverse effects. It is absolutely essential to ensure adequate overall nutritional and food intake with any fasting regimen. Always consult a healthcare provider before starting any fasting regimen.

  • Does Fasting Tonic replace all food during calorie restriction?

    No. While Fasting Tonic™ can support your body during a calorie restriction protocol, it is not a replacement for the balanced, nutrient-dense diet that complements it. Always strive to consume a variety of foods to get the full spectrum of nutrients your body needs.

References

  1. Reference link

    1. Gu L, Fu R, Hong J, Ni H, Yu K, Lou H. Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials. Front Nutr. 2022;9:871682.

  2. Reference link

    2. Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci U S A. 2004;101(17):6659-63.

  3. Reference link

    3. Attinà A, Leggeri C, Paroni R, Pivari F, Dei Cas M, Mingione A, et al. Fasting: How to guide. Nutrients. 2021;13(5):1570.

  4. Reference link

    4. Waziry R, Ryan CP, Corcoran DL, Huffman KM, Kobor MS, Kothari M, et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nature Aging. 2023;3(3):248-57.

  5. Reference link

    5. Calabrese EJ, Dhawan G, Kapoor R, Iavicoli I, Calabrese V. What is hormesis and its relevance to healthy aging and longevity? Biogerontology. 2015;16(6):693-707.

  6. Reference link

    6. Vaiserman AM. Hormesis, adaptive epigenetic reorganization, and implications for human health and longevity. Dose-Response. 2010;8(1):dose-response. 09-014. Vaiserman.

  7. Reference link

    7. Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017;39:46-58.

  8. Reference link

    8. Mattson MP. Challenging oneself intermittently to improve health. Dose Response. 2014;12(4):600-18.

  9. Reference link

    9. Shetty AK, Kodali M, Upadhya R, Madhu LN. Emerging Anti-Aging Strategies - Scientific Basis and Efficacy. Aging Dis. 2018;9(6):1165-84.

  10. Reference link

    10. Keithley J, Swanson B. Glucomannan and obesity: a critical review. Alternative therapies in health and medicine. 2005;11(6):30-4.

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